BIOMAT Database Logo BIOMAT Database Logo

Effect of steroid hormones and antihormones on hypothalamic beta-endorphin concentrations in intact and castrated female rats. 1990

A R Genazzani, and F Petraglia, and N Mercuri, and G Brilli, and A D Genazzani, and M Bergamaschi, and B M DeRamundo, and A Volpe
Istituto Clinica Ostetrica e Ginecologica, Università di Modena, Italy.

The aim of the present study was to evaluate the effects of estrogens and androgens on hypothalamic beta-endorphin (beta-EP) concentrations. Intact or castrated female rats were chronically (2 weeks) treated with estrogen (estradiol benzoate) and/or antiestrogens (clomiphene, cyclophenil or epimestrol), and with androgens (dihydrotestosterone or dehydroepiandrosterone sulphate) and/or antiandrogen (cyproterone acetate). A group of rats treated with vehicle were studied as comparison. The beta-EP concentrations were measured by radioimmunoassay on acidic extracts of rat hypothalami. The administration of clomiphene and cyclophenil significantly reduced hypothalamic beta-EP concentrations in intact rats, while both drugs or estradiol benzoate increased the peptide concentration in castrated rats. Both intact and castrated rats treated with epimestrol showed hypothalamic beta-EP concentrations higher than vehicle treated rats. The estradiol-induced increase of beta-EP was not changed by the concomitant administration of antiestrogens. The administration of dihydrotestosterone significantly decreased beta-EP concentrations in both intact and castrated female rats, while the treatment with dehydroepiandrosterone sulphate only slightly decreased beta-EP levels in intact female rats. The cyproterone acetate-chronically treated rats showed higher beta-EP concentrations than vehicle-treated rats and these changes were reversed by the concomitant addition of dihydrotestosterone or dehydroepiandrosterone sulphate. These results showed that estrogens play a positive role while androgens negatively influence the hypothalamic beta-EP concentrations in female rats, supporting the view that central beta-EP might be a target of gonadal steroid feedback signals.

UI MeSH Term Description Entries
D007031 Hypothalamus Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE. Lamina Terminalis,Preoptico-Hypothalamic Area,Area, Preoptico-Hypothalamic,Areas, Preoptico-Hypothalamic,Preoptico Hypothalamic Area,Preoptico-Hypothalamic Areas
D010052 Ovariectomy The surgical removal of one or both ovaries. Castration, Female,Oophorectomy,Bilateral Ovariectomy,Bilateral Ovariectomies,Castrations, Female,Female Castration,Female Castrations,Oophorectomies,Ovariectomies,Ovariectomies, Bilateral,Ovariectomy, Bilateral
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D002996 Clomiphene A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that ENCLOMIPHENE and ZUCLOMIPHENE are the (E) and (Z) isomers of Clomiphene respectively. Chloramiphene,Clomifene,Clomid,Clomide,Clomifen,Clomiphene Citrate,Clomiphene Hydrochloride,Clostilbegit,Dyneric,Gravosan,Klostilbegit,Serophene,Citrate, Clomiphene,Hydrochloride, Clomiphene
D003506 Cyclofenil A gonadal stimulant and inducer of ovulation. It is used in the treatment of infertility and amenorrhea, but is thought to be less effective than CLOMIPHENE. 4-((4-(Acetyloxy)phenyl)cyclohexylidenemethyl)phenol Acetate,Cyclophenil,F-6066,Ondogyne,F 6066,F6066
D003534 Cyproterone An anti-androgen that, in the form of its acetate (CYPROTERONE ACETATE), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females. Cyproterone, 1alpha,2 alpha,9 beta,10 alpha-Isomer
D003687 Dehydroepiandrosterone A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion. Dehydroisoandrosterone,Prasterone,5-Androsten-3-beta-hydroxy-17-one,5-Androsten-3-ol-17-one,Androstenolone,DHEA,Prasterone, 3 alpha-Isomer,5 Androsten 3 beta hydroxy 17 one,5 Androsten 3 ol 17 one,Prasterone, 3 alpha Isomer
D004836 Epimestrol A synthetic steroid with estrogenic activity. Stimuvol
D004958 Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. 17 beta-Estradiol,Estradiol-17 beta,Oestradiol,17 beta-Oestradiol,Aerodiol,Delestrogen,Estrace,Estraderm TTS,Estradiol Anhydrous,Estradiol Hemihydrate,Estradiol Hemihydrate, (17 alpha)-Isomer,Estradiol Monohydrate,Estradiol Valerate,Estradiol Valeriante,Estradiol, (+-)-Isomer,Estradiol, (-)-Isomer,Estradiol, (16 alpha,17 alpha)-Isomer,Estradiol, (16 alpha,17 beta)-Isomer,Estradiol, (17-alpha)-Isomer,Estradiol, (8 alpha,17 beta)-(+-)-Isomer,Estradiol, (8 alpha,17 beta)-Isomer,Estradiol, (9 beta,17 alpha)-Isomer,Estradiol, (9 beta,17 beta)-Isomer,Estradiol, Monosodium Salt,Estradiol, Sodium Salt,Estradiol-17 alpha,Estradiol-17beta,Ovocyclin,Progynon-Depot,Progynova,Vivelle,17 beta Estradiol,17 beta Oestradiol,Estradiol 17 alpha,Estradiol 17 beta,Estradiol 17beta,Progynon Depot
D004965 Estrogen Antagonists Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds. Estradiol Antagonists,Antagonists, Estradiol,Antagonists, Estrogen

Related Publications

A R Genazzani, and F Petraglia, and N Mercuri, and G Brilli, and A D Genazzani, and M Bergamaschi, and B M DeRamundo, and A Volpe
Effects of sex steroid hormones on arginine vasopressin in intact and castrated male and female rats.
January 1979, Endocrinology,
A R Genazzani, and F Petraglia, and N Mercuri, and G Brilli, and A D Genazzani, and M Bergamaschi, and B M DeRamundo, and A Volpe
The effect of chronic estrogen treatment on immunoreactive beta-endorphin levels in intact female rats.
July 1985, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
A R Genazzani, and F Petraglia, and N Mercuri, and G Brilli, and A D Genazzani, and M Bergamaschi, and B M DeRamundo, and A Volpe
Neurotransmitters and estrogen interact to affect beta-endorphin levels in castrated female rats.
January 1986, Peptides,
A R Genazzani, and F Petraglia, and N Mercuri, and G Brilli, and A D Genazzani, and M Bergamaschi, and B M DeRamundo, and A Volpe
Changes of beta-endorphin and somatostatin concentrations in different hypothalamic areas of female rats after chronic starvation.
August 1983, Life sciences,
A R Genazzani, and F Petraglia, and N Mercuri, and G Brilli, and A D Genazzani, and M Bergamaschi, and B M DeRamundo, and A Volpe
Immunoreactive beta-endorphin in the plasma, pituitary and hypothalamus of young female rats on the day of estrus and intact and chronically castrated old constant estrous female rats.
September 1983, Life sciences,
A R Genazzani, and F Petraglia, and N Mercuri, and G Brilli, and A D Genazzani, and M Bergamaschi, and B M DeRamundo, and A Volpe
Effect of beta-endorphin on pulsatile luteinizing hormone release in conscious castrated rats.
September 1980, Life sciences,
A R Genazzani, and F Petraglia, and N Mercuri, and G Brilli, and A D Genazzani, and M Bergamaschi, and B M DeRamundo, and A Volpe
[Effect of hypothalamic paraventricular beta-endorphin on burn shock in rats].
February 1995, Sheng li xue bao : [Acta physiologica Sinica],
A R Genazzani, and F Petraglia, and N Mercuri, and G Brilli, and A D Genazzani, and M Bergamaschi, and B M DeRamundo, and A Volpe
Effect of estetrol on Beta-Endorphin level in female rats.
March 2015, Steroids,
A R Genazzani, and F Petraglia, and N Mercuri, and G Brilli, and A D Genazzani, and M Bergamaschi, and B M DeRamundo, and A Volpe
Antiepileptic agents affect hypothalamic beta-endorphin concentrations.
September 1984, Journal of neurochemistry,
A R Genazzani, and F Petraglia, and N Mercuri, and G Brilli, and A D Genazzani, and M Bergamaschi, and B M DeRamundo, and A Volpe
Plasma gonadotropin concentrations in intact female and intact and castrated male prepubertal ponies.
April 1980, Biology of reproduction,
Copied contents to your clipboard!