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Discovery of novel methanone derivatives acting as antimycobacterial agents. 2011
Mohamed Ashraf Ali, and
Sylvaine Bastian, and
Rusli Ismail, and
Tan Soo Choon, and
Sadath Ali, and
Alexandra Aubry, and
Suresh Pandian, and
Pankaj Saraswat, and
Abhimanyu Singh, and
Ramakant Gaur
Pharmacogenetic and Novel Therapeutics Research, Institute for Research in Molecular Medicine, Universiti of Sains Malaysia, Pennag, Malaysia. asraf80med@rediffmail.com
A series of pyrazoline derivatives were synthesized and in vitro activity against Mycobacterium tuberculosis H37Rv was carried out. Among the synthesized compounds, compounds (4d) and (4f) 4-aminophenyl-3-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-ylmethanone and 4-aminophenyl-6,7-dimethoxy-3-phenyl-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-ylmethanone were found to be the most active agent against M. tuberculosis H37Rv with a minimum inhibitory concentration of 10 μg/mL.
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European journal of medicinal chemistry,
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Tan Soo Choon, and
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Bioorganic & medicinal chemistry letters,
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Sadath Ali, and
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Farmaco (Societa chimica italiana : 1989),
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Sylvaine Bastian, and
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Tan Soo Choon, and
Sadath Ali, and
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October 1994,
Archiv der Pharmazie,
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July 2013,
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Tan Soo Choon, and
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Pankaj Saraswat, and
Abhimanyu Singh, and
Ramakant Gaur
January 2010,
Bioorganic & medicinal chemistry letters,
