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We present here the molecular characterization of a new activation-induced surface structure on human T lymphocytes, termed LA45, with high homology (93% at protein level) to MHC class I molecules. Antigen modulation and sequential immunoprecipitation experiments revealed that LA45 and HLA class I proteins do not crossreact with the corresponding antibodies. Furthermore, LA45 is not associated with beta 2-m. On the other hand, we could show that the separation of HLA-A,B,C and beta 2m molecules, induced by SDS-denaturation, leads to a conformational change in the heavy chain in such a way that it becomes reactive with LA45. The 90/45 kD LA45 proteins thus appear to be non-beta 2m-associated MHC class I alpha chains that are selectively expressed by activated but not by resting human T lymphocytes.
E Schnabl, and
H Stockinger, and
O Majdic, and
H Gaugitsch, and
I J Lindley, and
D Maurer, and
A Hajek-Rosenmayr, and
W Knapp
July 1993,
Journal of immunology (Baltimore, Md. : 1950),
E Schnabl, and
H Stockinger, and
O Majdic, and
H Gaugitsch, and
I J Lindley, and
D Maurer, and
A Hajek-Rosenmayr, and
W Knapp
January 1985,
Immunogenetics,
E Schnabl, and
H Stockinger, and
O Majdic, and
H Gaugitsch, and
I J Lindley, and
D Maurer, and
A Hajek-Rosenmayr, and
W Knapp
November 1991,
The Journal of general virology,
E Schnabl, and
H Stockinger, and
O Majdic, and
H Gaugitsch, and
I J Lindley, and
D Maurer, and
A Hajek-Rosenmayr, and
W Knapp
December 1996,
Scandinavian journal of immunology,
E Schnabl, and
H Stockinger, and
O Majdic, and
H Gaugitsch, and
I J Lindley, and
D Maurer, and
A Hajek-Rosenmayr, and
W Knapp
January 2005,
Journal of immunology (Baltimore, Md. : 1950),
E Schnabl, and
H Stockinger, and
O Majdic, and
H Gaugitsch, and
I J Lindley, and
D Maurer, and
A Hajek-Rosenmayr, and
W Knapp
January 1984,
Experimental and clinical immunogenetics,
E Schnabl, and
H Stockinger, and
O Majdic, and
H Gaugitsch, and
I J Lindley, and
D Maurer, and
A Hajek-Rosenmayr, and
W Knapp
May 1996,
Immunology,
E Schnabl, and
H Stockinger, and
O Majdic, and
H Gaugitsch, and
I J Lindley, and
D Maurer, and
A Hajek-Rosenmayr, and
W Knapp
July 2002,
International immunology,
E Schnabl, and
H Stockinger, and
O Majdic, and
H Gaugitsch, and
I J Lindley, and
D Maurer, and
A Hajek-Rosenmayr, and
W Knapp
September 2000,
Journal of immunology (Baltimore, Md. : 1950),
E Schnabl, and
H Stockinger, and
O Majdic, and
H Gaugitsch, and
I J Lindley, and
D Maurer, and
A Hajek-Rosenmayr, and
W Knapp
November 1982,
Molecular immunology,
