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We developed a high performance liquid chromatography method for the monitoring of enoximone and its main metabolite in serum and urine. Samples handling involves a unique chemical extraction step by ethylacetate. Serum needs at first to be deproteinized by acetonitril. The chromatographic separation is realized on a reversed phase analytical column by gradient elution with acetonitrile. Quantification is by U.V. absorbance at 365 nm. We compared our new method with the method so far considered as reference one. When specificity, accuracy and linearity of both procedures are similar, we greatly enhanced the detection limit [(5 ng/ml for (E) and (SE)] and the practicability: ease of use, rapidity and lower cost.
E Tarral, and
F Jehl, and
C Gallion, and
H Monteil
December 1982,
Pharmaceutisch weekblad. Scientific edition,
E Tarral, and
F Jehl, and
C Gallion, and
H Monteil
May 1991,
Die Pharmazie,
E Tarral, and
F Jehl, and
C Gallion, and
H Monteil
October 1974,
The Journal of laboratory and clinical medicine,
E Tarral, and
F Jehl, and
C Gallion, and
H Monteil
March 1997,
Journal of chromatography. B, Biomedical sciences and applications,
E Tarral, and
F Jehl, and
C Gallion, and
H Monteil
August 1987,
Journal of chromatography,
E Tarral, and
F Jehl, and
C Gallion, and
H Monteil
July 1986,
Journal of chromatography,
E Tarral, and
F Jehl, and
C Gallion, and
H Monteil
January 1986,
Journal of chromatography,
E Tarral, and
F Jehl, and
C Gallion, and
H Monteil
April 1996,
Journal of chromatographic science,
E Tarral, and
F Jehl, and
C Gallion, and
H Monteil
April 1991,
Clinical chemistry,
E Tarral, and
F Jehl, and
C Gallion, and
H Monteil
October 1976,
Biochemical medicine,
