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The present study was designed to examine the effect of synthetic rat endothelin, a novel potent vasoconstrictor isolated from endothelial cells, on the release of immunoreactive atrial natriuretic factor (ir-ANF) in anesthetized rats. Systemic blood pressure and plasma ir-ANF concentration were measured at 1, 3, 5, 15, 30, and 60 minutes after rat endothelin administration (0.01, 0.10, 1.00 nmol/kg body weight [BW]). Administration of rat endothelin caused a long-lasting increase in mean blood pressure and produced a dose-dependent increase in plasma ir-ANF that peaked 5 minutes after the injection and remained higher than the basal value 60 minutes after the injection. These data suggest that administration of pharmacological doses of rat endothelin produces a profound release of ir-ANF into the circulation, which may cause vasodilation and diuresis to antagonize the effect of endothelin.
M Kohno, and
K Murakawa, and
T Horio, and
N Kurihara, and
K Yokokawa, and
K Yasunari, and
T Fukui, and
T Takeda
January 1988,
Peptides,
M Kohno, and
K Murakawa, and
T Horio, and
N Kurihara, and
K Yokokawa, and
K Yasunari, and
T Fukui, and
T Takeda
December 1988,
European journal of pharmacology,
M Kohno, and
K Murakawa, and
T Horio, and
N Kurihara, and
K Yokokawa, and
K Yasunari, and
T Fukui, and
T Takeda
July 1989,
Hypertension (Dallas, Tex. : 1979),
M Kohno, and
K Murakawa, and
T Horio, and
N Kurihara, and
K Yokokawa, and
K Yasunari, and
T Fukui, and
T Takeda
January 1989,
Life sciences,
M Kohno, and
K Murakawa, and
T Horio, and
N Kurihara, and
K Yokokawa, and
K Yasunari, and
T Fukui, and
T Takeda
March 1992,
American heart journal,
M Kohno, and
K Murakawa, and
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N Kurihara, and
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K Yasunari, and
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T Takeda
October 1990,
The Journal of laboratory and clinical medicine,
M Kohno, and
K Murakawa, and
T Horio, and
N Kurihara, and
K Yokokawa, and
K Yasunari, and
T Fukui, and
T Takeda
December 1989,
Hypertension (Dallas, Tex. : 1979),
M Kohno, and
K Murakawa, and
T Horio, and
N Kurihara, and
K Yokokawa, and
K Yasunari, and
T Fukui, and
T Takeda
October 1988,
The American journal of physiology,
M Kohno, and
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T Horio, and
N Kurihara, and
K Yokokawa, and
K Yasunari, and
T Fukui, and
T Takeda
August 1994,
The American journal of physiology,
M Kohno, and
K Murakawa, and
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N Kurihara, and
K Yokokawa, and
K Yasunari, and
T Fukui, and
T Takeda
October 1995,
The Journal of physiology,
