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The incidence of spontaneous thymic lymphoma has been studied in crosses between AKR/J and RF/J mice. AKR mice develop a high incidence of this disease. RF mice transmit a marked resistance to development of the disease to F1 hybrid mice of the AKR x RF cross. This resistance is associated with a reduction of endogenous ecotropic and xenotropic MuLV expression in the prelymphomatous thymus. The RF gene governing the coordinate suppression of these three phenotypes has been mapped to the Fv-1 locus. These results indicate that the particular Fv-1 allele of AKR mice provides a permissive genetic background for endogenous ecotropic and xenotropic MuLV expression and that these viral activities may be etiologically involved in the development of spontaneous thymic lymphoma in the mouse.
A Mayer, and
M L Duran-Reynals, and
F Lilly
December 1985,
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A Mayer, and
M L Duran-Reynals, and
F Lilly
April 1982,
Nature,
A Mayer, and
M L Duran-Reynals, and
F Lilly
October 1983,
International journal of cancer,
A Mayer, and
M L Duran-Reynals, and
F Lilly
January 1986,
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A Mayer, and
M L Duran-Reynals, and
F Lilly
September 1985,
Journal of the National Cancer Institute,
A Mayer, and
M L Duran-Reynals, and
F Lilly
November 1982,
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A Mayer, and
M L Duran-Reynals, and
F Lilly
April 1963,
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A Mayer, and
M L Duran-Reynals, and
F Lilly
January 1978,
Current topics in microbiology and immunology,
A Mayer, and
M L Duran-Reynals, and
F Lilly
February 1979,
Virology,
A Mayer, and
M L Duran-Reynals, and
F Lilly
September 1987,
Nucleic acids research,
