OBJECTIVE To report a case of toxic anterior uveitis probably secondary to the use of topical podophyllum. METHODS Case report, interventional. METHODS The authors present a 78-year-old male with acute anterior uveitis that developed within a couple of hours of application of topical podophyllum. In vivo confocal microscopy showed unique findings that disappeared following treatment with topical steroids alone. The patient reapplied podophyllum 2 months later and a recurrence of uveitis was noted. RESULTS A score of 7 was obtained using the adverse drug reaction probability scale, suggesting that the anterior uveitis is a probable adverse reaction to topical podophyllum. CONCLUSIONS Anterior uveitis may occur after topical application of podophyllum.