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For the purpose of the study of macroscopical and histopathological anti-cancer effects, preoperative cancer chemotherapy was performed in 31 cases with gastric carcinoma. Gastric carcinoma with preoperative chemotherapy showed advanced cancer in 15 cases, and early cancer in 16 cases. During preoperative chemotherapy, the drug 5-Fu or 5'-DFUR was administered orally. The results were as follows; i) Macroscopical change of early cancer cases with anti-cancer chemotherapy showed the onset and healing of ulceration in the cancerous lesion and the change of granular pattern in the IIc floor. ii) Early cancer cases had a multi-centric histopathological anti-cancer effect which showed regenerative epithelium in the cancerous lesion. iii) The extent of the histopathological anti-cancer effect in advanced carcinoma showed greater in the deep layer of cancer invasion. Consequently, morphological changes of early cancer cases with chemotherapy are similar to the cases without chemotherapy. The onset of cancer damage in advanced carcinoma is in the cancer invasive zone, deep layer.
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