Betel quid chewing elevates human exposure to arsenic, cadmium and lead. 2011

Shaban W Al-Rmalli, and Richard O Jenkins, and Parvez I Haris
Faculty of Health and Life Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK.

Several studies have reported increased skin lesions in betel quid (a mixture of Piper betel leaves, areca nut, tobacco/flavoured tobacco, lime) chewers compared to non-chewers, exposed to arsenic (As) contaminated drinking water in Bangladesh and India. The current study has determined As, cadmium (Cd) and lead (Pb) levels of betel quids and its components using inductively coupled plasma mass spectrometry (ICP-MS). The highest concentrations of As were found in slaked lime (4.56 mg kg(-1)) followed by Piper betel leaves (0.406 mg kg(-1)) and flavoured tobacco (zarda) (0.285 mg kg(-1)), with a mean concentrations of As in betel quids of 0.035 mg kg(-1) (SD 0.02 mg kg(-1)). Mean concentrations of Cd and Pb in ordinary quids were 0.028 (SD 0.07 mg kg(-1)) and 0.423 (SD 1.4 mg kg(-1)), respectively. We estimated that a daily intake of 6 betel quids could contribute 1.2, 1.9 and 8.5% of the provisional maximum tolerable daily intake (PMDTI) for As, Cd and Pb, respectively. Since betel quid chewing is most prevalent among women, our finding raises concern that women chewers - especially pregnant chewers - may be harming their health and that of their unborn babies through increased exposure to a mixture of toxic elements (As, Cd and Pb).

UI MeSH Term Description Entries
D007194 India A country in southern Asia, bordering the Arabian Sea and the Bay of Bengal, between Burma and Pakistan. The capitol is New Delhi. Republic of India
D007854 Lead A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.
D008297 Male Males
D008409 Mastication The act and process of chewing and grinding food in the mouth. Chewing
D008452 Maximum Allowable Concentration The maximum exposure to a biologically active physical or chemical agent that is allowed during an 8-hour period (a workday) in a population of workers, or during a 24-hour period in the general population, which does not appear to cause appreciable harm, whether immediate or delayed for any period, in the target population. (From Lewis Dictionary of Toxicology, 1st ed) Maximum Permissible Exposure Level,MPEL,Maximum Permissible Exposure Concentration,Allowable Concentration, Maximum,Allowable Concentrations, Maximum,Concentration, Maximum Allowable,Concentrations, Maximum Allowable,MPELs,Maximum Allowable Concentrations
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D002104 Cadmium An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001114 Areca A plant genus of the family ARECACEAE. Members contain ARECOLINE and CATECHIN. The leaves and nuts have been used as masticatories, stimulants, and astringents in traditional medicine. The common name of betel is also used for PIPER BETLE. The common name of catechu is sometimes used for ACACIA CATECHU. Betel Nut,Areca catechu,Areca catechus,Arecas,Betel Nuts,Nut, Betel,Nuts, Betel,catechus, Areca

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