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Enterovirus 71 meningoencephalitis complicating rituximab therapy. 2011
Rebekah Ahmed, and
Michael Buckland, and
Leo Davies, and
G Michael Halmagyi, and
Shannon L Rogers, and
Steven Oberste, and
Michael H Barnett
Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia.
We describe a fatal case of proven enterovirus 71 meningoencephalitis complicating monoclonal anti-CD20 antibody therapy for non-Hodgkin's lymphoma. B-cell depletion, an effective treatment strategy in an expanding spectrum of hematological and inflammatory disorders, impairs neutralising antibody-mediated clearance of enterovirus. The global threat of emerging neurotropic viruses such as enterovirus 71 is heightened by an increasing pool of susceptible individuals in non-endemic regions.
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