Biomaterial Database

Egg phosphatidylcholine liposomes incorporating hydrophobically modified chitosan: pH-sensitive release. 2011

Yeon-Ji Hong, and Jin-Chul Kim

School of Biotechnology and Bioengineering and Institute of Bioscience and Biotechnology Kangwon National University, 192-1, Hyoja 2-Dong, Chunchon, Kangwon-Do 200-701, Korea.

Egg phosphatidylcholine (EPC) liposomes incorporating hydrophobically modified chitosan (HmCh) were prepared by a sonication method. In order to immobilize chitosan on the surface of EPC liposomes, pentyl chains were covalently attached to chitosan. Following the proton NMR spectrum, the number of pentyl chains per chitosan molecule was calculated to be 2.5. Once the ratio of HmCh to EPC was kept below 1:5, the degrees of fluorescence quenching in the liposomal suspension were greater than 70%, indicating a high yield of liposome formation. No significant release from the liposome was observed in neutral and akali condition. The liposomes started to release their content at pH 6.5, and the release became more extensive as the pH of release medium decreased. The pH-sensitivity of the liposomes in terms of the release strongly depended on the amount of HmCh incorporated in liposomes.

UI	MeSH Term	Description	Entries
D008081	Liposomes	Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.	Niosomes,Transferosomes,Ultradeformable Liposomes,Liposomes, Ultra-deformable,Liposome,Liposome, Ultra-deformable,Liposome, Ultradeformable,Liposomes, Ultra deformable,Liposomes, Ultradeformable,Niosome,Transferosome,Ultra-deformable Liposome,Ultra-deformable Liposomes,Ultradeformable Liposome
D010713	Phosphatidylcholines	Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	Choline Phosphoglycerides,Choline Glycerophospholipids,Phosphatidyl Choline,Phosphatidyl Cholines,Phosphatidylcholine,Choline, Phosphatidyl,Cholines, Phosphatidyl,Glycerophospholipids, Choline,Phosphoglycerides, Choline
D004355	Drug Stability	The chemical and physical integrity of a pharmaceutical product.	Drug Shelf Life,Drugs Shelf Lives,Shelf Life, Drugs,Drug Stabilities,Drugs Shelf Life,Drugs Shelf Live,Life, Drugs Shelf,Shelf Life, Drug,Shelf Live, Drugs,Shelf Lives, Drugs
D004531	Eggs	Animal reproductive bodies, or the contents thereof, used as food. The concept is differentiated from OVUM, the anatomic or physiologic entity.
D005452	Fluoresceins	A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.	Tetraiodofluorescein
D006863	Hydrogen-Ion Concentration	The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH	pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D013010	Sonication	The application of high intensity ultrasound to liquids.	Sonications
D048271	Chitosan	Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.	Poliglusam
D057927	Hydrophobic and Hydrophilic Interactions	The thermodynamic interaction between a substance and WATER.	Hydrophilic Interactions,Hydrophilic and Hydrophobic Interactions,Hydrophilicity,Hydrophobic Interactions,Hydrophobicity,Hydrophilic Interaction,Hydrophilicities,Hydrophobic Interaction,Hydrophobicities,Interaction, Hydrophilic,Interaction, Hydrophobic,Interactions, Hydrophilic,Interactions, Hydrophobic