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Persistent etretinate levels in plasma after changing the therapy to acitretin. 1990

W E Lambert, and A P De Leenheer, and J P De Bersaques, and A Kint
Laboratoria voor Medische Biochemie en voor Klinische Analyse, Rijksuniversiteit Gent, Belgium.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D004347 Drug Interactions The action of a drug that may affect the activity, metabolism, or toxicity of another drug. Drug Interaction,Interaction, Drug,Interactions, Drug
D005050 Etretinate An oral retinoid used in the treatment of keratotic genodermatosis, lichen planus, and psoriasis. Beneficial effects have also been claimed in the prophylaxis of epithelial neoplasia. The compound may be teratogenic. B10-9359,Ethyl Etrinoate,Ro 10-9359,Ro-10-9359,Tigason,Tigazon,B10 9359,B109359,Etrinoate, Ethyl,Ro 10 9359,Ro 109359,Ro109359
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D012871 Skin Diseases Diseases involving the DERMIS or EPIDERMIS. Dermatoses,Skin and Subcutaneous Tissue Disorders,Dermatosis,Skin Disease
D014212 Tretinoin An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE). Retinoic Acid,Vitamin A Acid,Retin-A,Tretinoin Potassium Salt,Tretinoin Sodium Salt,Tretinoin Zinc Salt,Vesanoid,all-trans-Retinoic Acid,beta-all-trans-Retinoic Acid,trans-Retinoic Acid,Acid, Retinoic,Acid, Vitamin A,Acid, all-trans-Retinoic,Acid, beta-all-trans-Retinoic,Acid, trans-Retinoic,Potassium Salt, Tretinoin,Retin A,Salt, Tretinoin Potassium,Salt, Tretinoin Sodium,Salt, Tretinoin Zinc,Sodium Salt, Tretinoin,Zinc Salt, Tretinoin,all trans Retinoic Acid,beta all trans Retinoic Acid,trans Retinoic Acid
D017255 Acitretin An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of ETRETINATE with the advantage of a much shorter half-life when compared with etretinate. 13-cis-Acitretin,Etretin,Isoetretin,Acitretin, (Z,E,E,E)-Isomer,Isoacitretin,Neotigason,Ro 10-1670,Ro 13-7652,Ro-10-1670,Ro-13-7652,Soriatane,Ro 101670,Ro 137652,Ro101670,Ro137652

Related Publications

W E Lambert, and A P De Leenheer, and J P De Bersaques, and A Kint
Etretinate. Persistent serum levels after long-term therapy.
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Concentration of etretinate in plasma and subcutaneous fat after long-term acitretin.
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Comparative binding of etretinate and acitretin to plasma proteins and erythrocytes.
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Inability to detect plasma etretinate and acitretin is a poor predictor of the absence of these teratogens in tissue after stopping acitretin treatment.
September 1994, British journal of clinical pharmacology,
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Pharmacokinetics of acitretin and etretinate.
August 1998, Journal of the American Academy of Dermatology,
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[Trans-acitretin is metabolized back to etretinate. Importance for oral retinoid therapy].
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Etretinate may work where acitretin fails.
March 1997, The British journal of dermatology,
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Teratogenic risk with etretinate and acitretin treatment.
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Acitretin is converted to etretinate only during concomitant alcohol intake.
December 2000, The British journal of dermatology,
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Clinical Factors Affecting the Serum Retention of a Teratogenic Etretinate after the Acitretin Administration.
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