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Absence of abnormalities of the c-erbB-1 and c-erbB-2 proto-oncogenes in human thyroid neoplasia. 1990
N R Lemoine, and
F S Wyllie, and
J R Lillehaug, and
S L Staddon, and
C M Hughes, and
R Aasland, and
J Shaw, and
J E Varhaug, and
C L Brown, and
W J Gullick
ICRF Molecular Oncology Group, Hammersmith Hospital, London, U.K.
The c-erbB-1 and c-erbB-2 proto-oncogenes are frequently activated by gene amplification and overexpression in a variety of human cancers. In an analysis of a large series of benign and malignant thyroid tumours, no abnormalities of structure or expression of either of c-erbB-1 or c-erbB-2 were found. Activation of these oncogenes is not a necessary event in neoplasia of this epithelial system.
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