Biomaterial Database

Tyrosinase inhibitory potential of natural products isolated from various medicinal plants. 2011

Azizuddin, and A Majeed Khan, and M Iqbal Choudhary

Department of Chemistry, Federal Urdu University for Arts, Science and Technology,Gulshan-e-Iqbal Campus, Karachi 75300, Pakistan. azizpobox1@yahoo.com

Seven secondary metabolites, p-hydroxybenzoic acid (1), 3,4-dihydroxybenzoic acid (2), ferulic acid (3), 2,6-dimethoxy-4-hydroxy acetophenone (4), lupeol (5), 2'-O-ethylmurrangatin (6) and hibiscetin heptamethyl ether (7) were the natural products isolated from various medicinal plants. Their structures were identified by spectral comparison with previously reported data. The compounds 1-7 were screened for their tyrosinase-inhibitory activity. The compound p-hydroxybenzoic acid (1) was found to have potent activity against tyrosinase enzyme, whereas lupeol (5) showed significant activity.

UI	MeSH Term	Description	Entries
D010936	Plant Extracts	Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.	Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D010946	Plants, Medicinal	Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.	Herbs, Medicinal,Medicinal Herbs,Healing Plants,Medicinal Plants,Pharmaceutical Plants,Healing Plant,Herb, Medicinal,Medicinal Herb,Medicinal Plant,Pharmaceutical Plant,Plant, Healing,Plant, Medicinal,Plant, Pharmaceutical,Plants, Healing,Plants, Pharmaceutical
D003373	Coumaric Acids	Hydroxycinnamic acid and its derivatives. Act as activators of the indoleacetic acid oxidizing system, thereby producing a decrease in the endogenous level of bound indoleacetic acid in plants.	Coumaric Acid,Hydroxycinnamic Acid,Hydroxycinnamic Acids,Acid, Coumaric,Acid, Hydroxycinnamic,Acids, Coumaric,Acids, Hydroxycinnamic
D003374	Coumarins	Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid.	1,2-Benzopyrone Derivatives,1,2-Benzopyrones,Coumarin Derivative,Coumarine,1,2-Benzo-Pyrones,Benzopyran-2-ones,Coumarin Derivatives,Coumarines,1,2 Benzo Pyrones,1,2 Benzopyrone Derivatives,1,2 Benzopyrones,Benzopyran 2 ones,Derivative, Coumarin,Derivatives, 1,2-Benzopyrone,Derivatives, Coumarin
D000098	Acetophenones	Derivatives of the simplest aromatic ketone acetophenone (of general formula C6H5C(O)CH3).
D014442	Monophenol Monooxygenase	An enzyme of the oxidoreductase class that catalyzes the reaction between L-tyrosine, L-dopa, and oxygen to yield L-dopa, dopaquinone, and water. It is a copper protein that acts also on catechols, catalyzing some of the same reactions as CATECHOL OXIDASE. EC 1.14.18.1.	Dopa Oxidase,Phenoloxidase,Tyrosinase,Cresolase,Phenol Oxidase,Phenoloxidase A,Phenoloxidase B,Monooxygenase, Monophenol,Oxidase, Dopa,Oxidase, Phenol
D015394	Molecular Structure	The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.	Structure, Molecular,Molecular Structures,Structures, Molecular
D047309	Flavones	A group of 4-keto-FLAVONOIDS.	2-Phenyl-2-Ene-Benzopyran-4-One Compounds
D053978	Pentacyclic Triterpenes	Five-ring derivatives of dammarane having a chair-chair-chair-boat configuration. They include the lupanes, oleananes, amyrins, GLYCYRRHIZIC ACID, and soyasaponins.	Adianane Derivatives,Adiananes,Baccharane Triterpenes,Fernane Derivatives,Fernanes,Gammacerane Derivatives,Gammaceranes,Hopane Derivatives,Hopanes,Hopenoid Derivatives,Pentacyclic Triterpenoids,Triterpenes, Pentacyclic,Triterpenes, Baccharane
D062385	Hydroxybenzoates	Benzoate derivatives substituted by one or more hydroxy groups in any position on the benzene ring.	Hydroxybenzoic Acids,Acids, Hydroxybenzoic