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This study examines prostacyclin production by blood-contacting surfaces within woven vascular prostheses of polydioxanone (PDS), polyglactin 910 (PG910), or Dacron interposed into rabbit infrarenal aortas. Grafts and normal aortic segments were explanted after 1, 3, and 6 months for pulsatile perfusion with Medium-199 for 60 minutes. Aliquots were removed serially for 6-keto-PGF1 alpha assay. After 30 minutes sodium arachidonate (10 micrograms/ml) was added. Specimens were studied by light microscopy, SEM and TEM. Patency in all three groups exceeded 90%. All three showed re-endothelialization at one month. Normal aorta produced low basal 6-keto-PGF1 alpha with a marked evanescent post arachidonate increase. Dacron did not differ from normal aorta. PG910 and PDS both produced significantly less 6-keto-PGF1 alpha post arachidonate at one month but both increased to normal by three months.
H P Greisler, and
J J Klosak, and
J F McGurrin, and
E D Endean, and
J Ellinger, and
J D Pozar, and
S C Henderson, and
D U Kim
October 1978,
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H P Greisler, and
J J Klosak, and
J F McGurrin, and
E D Endean, and
J Ellinger, and
J D Pozar, and
S C Henderson, and
D U Kim
September 1992,
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H P Greisler, and
J J Klosak, and
J F McGurrin, and
E D Endean, and
J Ellinger, and
J D Pozar, and
S C Henderson, and
D U Kim
January 1979,
Haemostasis,
H P Greisler, and
J J Klosak, and
J F McGurrin, and
E D Endean, and
J Ellinger, and
J D Pozar, and
S C Henderson, and
D U Kim
January 1987,
Annals of the New York Academy of Sciences,
H P Greisler, and
J J Klosak, and
J F McGurrin, and
E D Endean, and
J Ellinger, and
J D Pozar, and
S C Henderson, and
D U Kim
March 1981,
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H P Greisler, and
J J Klosak, and
J F McGurrin, and
E D Endean, and
J Ellinger, and
J D Pozar, and
S C Henderson, and
D U Kim
June 1978,
Lancet (London, England),
H P Greisler, and
J J Klosak, and
J F McGurrin, and
E D Endean, and
J Ellinger, and
J D Pozar, and
S C Henderson, and
D U Kim
August 2021,
Biomaterials research,
H P Greisler, and
J J Klosak, and
J F McGurrin, and
E D Endean, and
J Ellinger, and
J D Pozar, and
S C Henderson, and
D U Kim
May 1979,
Nature,
H P Greisler, and
J J Klosak, and
J F McGurrin, and
E D Endean, and
J Ellinger, and
J D Pozar, and
S C Henderson, and
D U Kim
September 1986,
Biochemical pharmacology,
H P Greisler, and
J J Klosak, and
J F McGurrin, and
E D Endean, and
J Ellinger, and
J D Pozar, and
S C Henderson, and
D U Kim
October 1982,
Biochemical pharmacology,
