-transparent.png){kind=logo}
Uromodulin is an 85 Kd immunosuppressive glycoprotein originally isolated from human pregnancy urine. It is unique in that most of its biologic activity can be attributed to attached oligosaccharides. Purified immunomodulatory oligosaccharides from uromodulin have been structurally characterized using 1H-NMR spectroscopy and shown to be Man6-7GlcNAc2(M6,M7). Based on these observations, we isolated high-mannose N-type oligosaccharides and glycopeptides from ovalbumin, soybean agglutinin, and yeast mannan and show that these high-mannose compounds directly inhibit in vitro antigen-driven T-cell proliferation from millimolar to nanomolar concentrations. The most active compound was a core mannose oligosaccharide derived from yeast mannan, M9(y), which acts to block early events required for normal antigen processing/presentation. These data emphasize the potential functional role of carbohydrate structure in regulating the human immune response.
A V Muchmore, and
N Sathyamoorthy, and
J Decker, and
A P Sherblom
November 1997,
Diabetologia,
A V Muchmore, and
N Sathyamoorthy, and
J Decker, and
A P Sherblom
July 1993,
The Journal of experimental medicine,
A V Muchmore, and
N Sathyamoorthy, and
J Decker, and
A P Sherblom
December 1983,
Journal of immunology (Baltimore, Md. : 1950),
A V Muchmore, and
N Sathyamoorthy, and
J Decker, and
A P Sherblom
June 1993,
Blood,
A V Muchmore, and
N Sathyamoorthy, and
J Decker, and
A P Sherblom
April 1996,
Current opinion in immunology,
A V Muchmore, and
N Sathyamoorthy, and
J Decker, and
A P Sherblom
December 2006,
Proceedings of the National Academy of Sciences of the United States of America,
A V Muchmore, and
N Sathyamoorthy, and
J Decker, and
A P Sherblom
May 1984,
Proceedings of the National Academy of Sciences of the United States of America,
A V Muchmore, and
N Sathyamoorthy, and
J Decker, and
A P Sherblom
July 1984,
Transplantation,
A V Muchmore, and
N Sathyamoorthy, and
J Decker, and
A P Sherblom
November 2008,
Clinical and vaccine immunology : CVI,
A V Muchmore, and
N Sathyamoorthy, and
J Decker, and
A P Sherblom
March 1999,
Immunology letters,
