Cotranscriptional assembly of mRNP complexes that determine the cytoplasmic fate of mRNA. 2011

Amélie Forget, and Pascal Chartrand
Département de Biochimie; Université de Montréal; Montréal QC Canada.

Unlike prokaryotes, in which transcription and translation are coupled, eukaryotes physically separate transcription in the nucleus from mRNA translation and degradation in the cytoplasm. However, recent evidence has revealed that the full picture is more complex and that the nuclear transcription machinery plays specific roles in regulating the cytoplasmic fate of mRNA.

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