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Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action. 2011
Luis Berrade, and
Bárbara Aisa, and
María J Ramirez, and
Silvia Galiano, and
Salvatore Guccione, and
Lise Román Moltzau, and
Finn Olav Levy, and
Ferdinando Nicoletti, and
Giuseppe Battaglia, and
Gemma Molinaro, and
Ignacio Aldana, and
Antonio Monge, and
Silvia Perez-Silanes
Unidad en Investigación y Desarrollo de Medicamentos, Centro de Investigación en Farmacobiología Aplicada (CIFA), University of Navarra, Pamplona, Spain.
We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT(7)R and 5-HTT were selected to probe their antidepressant activity in vivo using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.
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