-transparent.png){kind=logo}
In acutely isolated spinal dorsal horn neurons of the rat, effects of serotonin (5-hydroxytryptamine, 5-HT) on inward current induced by excitatory amino acids were studied under whole-cell voltage-clamp condition. 5-HT suppressed the response to N-methyl-D-aspartate (NMDA), but not the response to kainate or quisqualate. This inhibitory effect of 5-HT on NMDA response was present at 5-HT concentrations as low as 10(-15) M. Although the 5-HT effect exhibited similar pharmacology to the 5-HT1A-type receptors, it was not mimicked by increasing intracellular concentration of adenosine 3',5'-cyclic monophosphate that is the common second messenger for 5-HT1A receptors in the mammalian central nervous system. Glycine strongly antagonized this inhibitory effect of 5-HT, and 5-HT reduced opening of NMDA-gated single channels recorded from the outside-out membrane patch. These lines of evidence are consistent with a possibility that 5-HT might directly modulate the NMDA receptor-ion channel complex, either by interacting with the regulatory site(s) or by acting on a distinct site.
K Murase, and
M Randic, and
T Shirasaki, and
T Nakagawa, and
N Akaike
March 1993,
Journal of neurochemistry,
K Murase, and
M Randic, and
T Shirasaki, and
T Nakagawa, and
N Akaike
November 1993,
Neuron,
K Murase, and
M Randic, and
T Shirasaki, and
T Nakagawa, and
N Akaike
June 2012,
Molecular pain,
K Murase, and
M Randic, and
T Shirasaki, and
T Nakagawa, and
N Akaike
May 2002,
Neuroscience letters,
K Murase, and
M Randic, and
T Shirasaki, and
T Nakagawa, and
N Akaike
July 1990,
Brain research,
K Murase, and
M Randic, and
T Shirasaki, and
T Nakagawa, and
N Akaike
December 1987,
Neuroscience letters,
K Murase, and
M Randic, and
T Shirasaki, and
T Nakagawa, and
N Akaike
February 2000,
Molecular pharmacology,
K Murase, and
M Randic, and
T Shirasaki, and
T Nakagawa, and
N Akaike
October 1993,
Neuroscience letters,
K Murase, and
M Randic, and
T Shirasaki, and
T Nakagawa, and
N Akaike
August 2008,
Anesthesia and analgesia,
K Murase, and
M Randic, and
T Shirasaki, and
T Nakagawa, and
N Akaike
August 1994,
Proceedings of the National Academy of Sciences of the United States of America,
