Role of quercetin on PCBs (Aroclor-1254) induced impairment of dopaminergic receptor mRNA expression in cerebral cortex of adult male rats. 2011

Rasiah Pratheepa Kumari, and Kandaswamy Selvakumar, and Senthamilselvan Bavithra, and Rafiq Zumaana, and Gunasekaran Krishnamoorthy, and Jagadeesan Arunakaran
Department of Biotechnology, Bharathidasan University, Trichy, 620024, India.

The present study is aimed to evaluate the putative neuroprotective effect of quercetin on PCB induced impairment of dopaminergic receptor mRNA expression in cerebral cortex of adult male Wistar rats. Group I (control) received only vehicle (corn oil; 0.1 ml/kg bwt) intraperitoneally (i.p); Group II Aroclor 1254 at a dose of 2 mg/kg bwt/day (i.p); Group III (Aroclor 1254-exposed (i.p), quercetin treated gavage (50 mg/kg bwt/day); Group IV received quercetin alone (gavage). 24 h after the 30th day treatment rats were euthanized. From each rat cerebral cortex tissues was collected and analyzed for mean activities of creatine kinase, acetylcholine esterase, Na(+)/K(+), Ca(2+) and Mg(2+)ATPases, Hydrogen peroxide generation, protein carbonyl content and lipid peroxidation levels. The fates of the mRNA expression of dopaminergic receptors, Cacna1d on all the groups were studied by RT-PCR. Results evidenced that significant reduction of neurodegeneration in PCBs exposed rats treated with quercetin was ascertained suggesting, quercetin treatment precludes against PCB induced oxidative stress and protects dopaminergic receptor dysfunction in rat cerebral cortex.

UI MeSH Term Description Entries
D008297 Male Males
D011078 Polychlorinated Biphenyls Industrial products consisting of a mixture of chlorinated biphenyl congeners and isomers. These compounds are highly lipophilic and tend to accumulate in fat stores of animals. Many of these compounds are considered toxic and potential environmental pollutants. PCBs,Polychlorinated Biphenyl,Polychlorobiphenyl Compounds,Biphenyl, Polychlorinated,Biphenyls, Polychlorinated,Compounds, Polychlorobiphenyl
D011794 Quercetin A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin. 3,3',4',5,7-Pentahydroxyflavone,Dikvertin
D011954 Receptors, Dopamine Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells. Dopamine Receptors,Dopamine Receptor,Receptor, Dopamine
D002540 Cerebral Cortex The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulci. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions. Allocortex,Archipallium,Cortex Cerebri,Cortical Plate,Paleocortex,Periallocortex,Allocortices,Archipalliums,Cerebral Cortices,Cortex Cerebrus,Cortex, Cerebral,Cortical Plates,Paleocortices,Periallocortices,Plate, Cortical
D003402 Creatine Kinase A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins. Creatine Phosphokinase,ADP Phosphocreatine Phosphotransferase,ATP Creatine Phosphotransferase,Macro-Creatine Kinase,Creatine Phosphotransferase, ATP,Kinase, Creatine,Macro Creatine Kinase,Phosphocreatine Phosphotransferase, ADP,Phosphokinase, Creatine,Phosphotransferase, ADP Phosphocreatine,Phosphotransferase, ATP Creatine
D006861 Hydrogen Peroxide A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials. Hydrogen Peroxide (H2O2),Hydroperoxide,Oxydol,Perhydrol,Superoxol,Peroxide, Hydrogen
D000110 Acetylcholinesterase An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7. Acetylcholine Hydrolase,Acetylthiocholinesterase,Hydrolase, Acetylcholine
D000251 Adenosine Triphosphatases A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA. ATPases,Adenosinetriphosphatase,ATPase,ATPase, DNA-Dependent,Adenosine Triphosphatase,DNA-Dependent ATPase,DNA-Dependent Adenosinetriphosphatases,ATPase, DNA Dependent,Adenosinetriphosphatases, DNA-Dependent,DNA Dependent ATPase,DNA Dependent Adenosinetriphosphatases,Triphosphatase, Adenosine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Rasiah Pratheepa Kumari, and Kandaswamy Selvakumar, and Senthamilselvan Bavithra, and Rafiq Zumaana, and Gunasekaran Krishnamoorthy, and Jagadeesan Arunakaran
December 2012, Journal of biochemical and molecular toxicology,
Rasiah Pratheepa Kumari, and Kandaswamy Selvakumar, and Senthamilselvan Bavithra, and Rafiq Zumaana, and Gunasekaran Krishnamoorthy, and Jagadeesan Arunakaran
July 1984, Bulletin of environmental contamination and toxicology,
Rasiah Pratheepa Kumari, and Kandaswamy Selvakumar, and Senthamilselvan Bavithra, and Rafiq Zumaana, and Gunasekaran Krishnamoorthy, and Jagadeesan Arunakaran
December 2019, Journal of immunotoxicology,
Rasiah Pratheepa Kumari, and Kandaswamy Selvakumar, and Senthamilselvan Bavithra, and Rafiq Zumaana, and Gunasekaran Krishnamoorthy, and Jagadeesan Arunakaran
January 1979, Bulletin of environmental contamination and toxicology,
Rasiah Pratheepa Kumari, and Kandaswamy Selvakumar, and Senthamilselvan Bavithra, and Rafiq Zumaana, and Gunasekaran Krishnamoorthy, and Jagadeesan Arunakaran
November 2007, Toxicology,
Rasiah Pratheepa Kumari, and Kandaswamy Selvakumar, and Senthamilselvan Bavithra, and Rafiq Zumaana, and Gunasekaran Krishnamoorthy, and Jagadeesan Arunakaran
February 2010, Neuroscience research,
Rasiah Pratheepa Kumari, and Kandaswamy Selvakumar, and Senthamilselvan Bavithra, and Rafiq Zumaana, and Gunasekaran Krishnamoorthy, and Jagadeesan Arunakaran
July 2013, Drug and chemical toxicology,
Rasiah Pratheepa Kumari, and Kandaswamy Selvakumar, and Senthamilselvan Bavithra, and Rafiq Zumaana, and Gunasekaran Krishnamoorthy, and Jagadeesan Arunakaran
March 1985, Bulletin of environmental contamination and toxicology,
Rasiah Pratheepa Kumari, and Kandaswamy Selvakumar, and Senthamilselvan Bavithra, and Rafiq Zumaana, and Gunasekaran Krishnamoorthy, and Jagadeesan Arunakaran
December 2004, Neurotoxicology,
Rasiah Pratheepa Kumari, and Kandaswamy Selvakumar, and Senthamilselvan Bavithra, and Rafiq Zumaana, and Gunasekaran Krishnamoorthy, and Jagadeesan Arunakaran
April 2012, Neurochemical research,
Copied contents to your clipboard!