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Pseudoprogression following concurrent temozolomide and radiotherapy in a patient with glioblastoma: findings on functional imaging techniques. 2010
Yuko Shirakawa, and
Takashi Yoshiura, and
Akio Hiwatashi, and
Koji Yamashita, and
Hironori Kamano, and
Yoshiyuki Shioyama, and
Kouichiro Abe, and
Toshiyuki Amano, and
Akira Nakamizo, and
Koji Yoshimoto, and
Hiroyuki Honda, and
Rina Torisu, and
Satoshi Suzuki, and
Hiroshi Honda
Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Concurrent temozolomide (TMZ) and radiotherapy became the new standard of care for patients diagnosed with glioblastoma multiforme (GBM). Recently, there has been an increasing awareness of progressive and enhancing lesions on MR images immediately after treatment. These lesions may be a treatment effect, so-called pseudoprogression. We experienced one case pathologically and clinically diagnosed as pseudoprogression. The lesion showed a high apparent diffusion coefficient on diffusion-weighted imaging, low blood volume on perfusion imaging, and low uptake of 18F-fluorodeoxyglucose on positron emission tomography. The lesion was pathologically diagnosed as pseudoprogression after additional surgical resection.
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