Biomaterial Database

The influence of inhaled fluticasone on bone metabolism and calciuria in asthmatic children. 2011

Radmila Ljuština-Pribić, and Vesna Stojanović, and Slobodanka Petrović

Department of Pulmology, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia.

BACKGROUND Inhaled corticosteroids have become the first-line medication for treatment of childhood asthma. Possible adverse effects, such as those on bone metabolism and urinary excretion of calcium are in the focus of interest. We investigated the influence of inhaled fluticasone on bone metabolism and renal excretion of calcium, sodium, and potassium in asthmatic children. METHODS Thirty asthmatic patients (mean age 12.24 ± 2.75 years) treated with 200-250 μg/day inhaled fluticasone were enrolled in the study. Prior to the initiation of therapy, as well as 12 weeks after following parameters were measured: serum sodium, potassium, calcium, phosphorus, creatinine, alkaline phosphatase, osteocalcin, intact parathyroid hormone levels, first-spot morning urine calcium/creatinine ratio, sodium/potassium ratio, and daily renal calcium excretion rate. RESULTS Serum electrolytes, alkaline phosphatase, parathyroid hormone, osteocalcin levels, as well as urinary calcium, sodium, and potassium excretion were within normal ranges. There was no statistical difference between values of those parameters prior and 12 weeks after initiation of the therapy. CONCLUSIONS Treatment with 200-250 μg/day inhaled fluticasone, in asthmatic children aged 9-16, during 12 weeks, did not affect serum osteocalcin level and renal excretion of calcium, sodium, and potassium.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D011188	Potassium	An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D011446	Prospective Studies	Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.	Prospective Study,Studies, Prospective,Study, Prospective
D001842	Bone and Bones	A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principal cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.	Bone Tissue,Bone and Bone,Bone,Bones,Bones and Bone,Bones and Bone Tissue,Bony Apophyses,Bony Apophysis,Condyle,Apophyses, Bony,Apophysis, Bony,Bone Tissues,Condyles,Tissue, Bone,Tissues, Bone
D002118	Calcium	A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.	Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000068298	Fluticasone	A STEROID with GLUCOCORTICOID RECEPTOR activity that is used to manage the symptoms of ASTHMA; ALLERGIC RHINITIS, and ATOPIC DERMATITIS.	Cutivate,Flixonase,Flixotide,Flonase,Flovent,Flovent HFA,Fluticasone Propionate,HFA, Flovent,Propionate, Fluticasone
D000280	Administration, Inhalation	The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.	Drug Administration, Inhalation,Drug Administration, Respiratory,Drug Aerosol Therapy,Inhalation Drug Administration,Inhalation of Drugs,Respiratory Drug Administration,Aerosol Drug Therapy,Aerosol Therapy, Drug,Drug Therapy, Aerosol,Inhalation Administration,Administration, Inhalation Drug,Administration, Respiratory Drug,Therapy, Aerosol Drug,Therapy, Drug Aerosol