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Goat antibodies developed against pure rabbit pulmonary angiotensin-converting enzyme (peptidyl dipeptidase, EC 3.4.15.1) were administered intravenously to rats with two-kidney Goldblatt hypertension and to normotensive animals. In the hypertensive model these antibodies were associated with a sustained, immune-dependent decrease of blood pressure to normal values. A smaller, but also immune-specific, reduction of blood pressure was observed in the normotensive group. The data suggest that heterologous antibody directed against angiotensin-converting enzyme may provide a biologically specific probe for examining the contribution of the renin-angiotensin system to normal and pathologic circulatory states.
R A Markle, and
E H Sonnenblick, and
J M Conroy, and
R L Soffer
January 1993,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
R A Markle, and
E H Sonnenblick, and
J M Conroy, and
R L Soffer
December 1993,
Kidney international,
R A Markle, and
E H Sonnenblick, and
J M Conroy, and
R L Soffer
September 1989,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
R A Markle, and
E H Sonnenblick, and
J M Conroy, and
R L Soffer
October 1988,
American journal of hypertension,
R A Markle, and
E H Sonnenblick, and
J M Conroy, and
R L Soffer
October 1988,
Hypertension (Dallas, Tex. : 1979),
R A Markle, and
E H Sonnenblick, and
J M Conroy, and
R L Soffer
August 1995,
Cardiovascular research,
R A Markle, and
E H Sonnenblick, and
J M Conroy, and
R L Soffer
August 1986,
Hypertension (Dallas, Tex. : 1979),
R A Markle, and
E H Sonnenblick, and
J M Conroy, and
R L Soffer
January 1986,
American journal of nephrology,
R A Markle, and
E H Sonnenblick, and
J M Conroy, and
R L Soffer
December 1991,
American journal of hypertension,
R A Markle, and
E H Sonnenblick, and
J M Conroy, and
R L Soffer
January 1984,
Lancet (London, England),
