The most significant complication of liver cirrhosis is the syndrome of portal hypertension. Varicose veins of the esophagus and stomach diagnosed in 50-80% of patients with liver cirrhosis and complicated by hemorrhage in 30-50%. The risk of bleeding is determined by the size of varicose veins, severity of liver cirrhosis, severity of inflammatory changes of esophageal mucosa. Conservative treatments don't always yield the desired result, which motivates the search for new pharmacological treatments of portal hypertension complications. OBJECTIVE To evaluate the effectiveness of flavonoids diosmin with hesperidin using at liver cirrhosis with varying degrees of portal hypertension severity. METHODS The study was based on the analysis of complex clinical, laboratory and instrumental examination of 125 patients with cirrhosis of different etiologies. The study didn't include patients with the presence of VEV III degree; hepatocellular insufficiency C class on the Child-Pugh classification; extrahepatic form of portal hypertension and patients with circulatory failure requiring continuous drug therapy. The ratio of male and female studied patients was 71 (56.8%) and 54 (43.2%), respectively, at the age of 33 to 74 years (mean age 52.8 +/- 5.7 years). According to etiology of the disease, all patients were divided into two groups. The first group included 82 (65.6%) patients, the cause of the LC was the abuse of alcohol, second group--43 (34.4%) persons with a viral etiology of LP (HBV or HCV). Endoscopic assessment of the VEV was perfomed by KJ Paquet classification (1983). All patients received therapy with flavonoids (diosmin with hesperidin) for 12 weeks. Efficacy of treatment was evaluated by endoscopic picture of the esophageal mucosa and the state of VEV at 4 and 12 weeks. RESULTS Treatment with the flavonoids hesperidin with diasminom showed a positive result in the form of reducing the VEV and reduced the number of varicose veins with a statistically significant in patients with alcoholic liver cirrhosis (p < 0.05). CONCLUSIONS The results indicated the effectiveness of therapy with flavonoids hesperidin with diasmin at portal hypertension in patients with alcoholic cirrhosis, which allows to include them in the complex treatment of medicamental prophylaxis of variceal bleeding.