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A minor population of T cells expresses a heterodimeric antigen receptor composed of gamma and delta chains (TcR-1). In blood from adults, two subsets of T gamma delta cells can be identified by the monoclonal antibodies (MoAb) BB3 and A13. Little is known about the distribution and markers of these subsets early in life. We have therefore examined both the frequencies of these cells in cord blood and their expression of the cytotoxicity-associated marker serine esterase (SE), using immunocytochemical techniques. Our data show lower percentages of TcR-1+ cells in the blood of newborns compared with that in adults. However, the ratio of the A13+/BB3+ cells was significantly higher in cord than in adult blood. Whereas virtually all the adult TcR-1+ cells in blood were SE-positive, only a small proportion of the cord blood cells carried this enzyme. This was restricted to the BB3+ T gamma delta-cell subset in the cord. Our data suggest different characteristics of the TcR-1+ cells in blood from newborns compared with adult blood, and study of the functions of the different subsets, e.g. cytotoxicity, will be important in understanding their particular role in immunity.
M D Smith, and
C Worman, and
F Yüksel, and
B Yüksel, and
L Moretta, and
E Ciccone, and
C E Grossi, and
L MacKenzie, and
P M Lydyard
January 2001,
Chemical immunology,
M D Smith, and
C Worman, and
F Yüksel, and
B Yüksel, and
L Moretta, and
E Ciccone, and
C E Grossi, and
L MacKenzie, and
P M Lydyard
January 1996,
Current topics in microbiology and immunology,
M D Smith, and
C Worman, and
F Yüksel, and
B Yüksel, and
L Moretta, and
E Ciccone, and
C E Grossi, and
L MacKenzie, and
P M Lydyard
January 1991,
Current topics in microbiology and immunology,
M D Smith, and
C Worman, and
F Yüksel, and
B Yüksel, and
L Moretta, and
E Ciccone, and
C E Grossi, and
L MacKenzie, and
P M Lydyard
February 1989,
Clinical and experimental immunology,
M D Smith, and
C Worman, and
F Yüksel, and
B Yüksel, and
L Moretta, and
E Ciccone, and
C E Grossi, and
L MacKenzie, and
P M Lydyard
January 1992,
Annual review of immunology,
M D Smith, and
C Worman, and
F Yüksel, and
B Yüksel, and
L Moretta, and
E Ciccone, and
C E Grossi, and
L MacKenzie, and
P M Lydyard
February 2000,
The Journal of molecular diagnostics : JMD,
M D Smith, and
C Worman, and
F Yüksel, and
B Yüksel, and
L Moretta, and
E Ciccone, and
C E Grossi, and
L MacKenzie, and
P M Lydyard
December 1988,
Journal of immunology (Baltimore, Md. : 1950),
M D Smith, and
C Worman, and
F Yüksel, and
B Yüksel, and
L Moretta, and
E Ciccone, and
C E Grossi, and
L MacKenzie, and
P M Lydyard
August 1990,
Scandinavian journal of immunology,
M D Smith, and
C Worman, and
F Yüksel, and
B Yüksel, and
L Moretta, and
E Ciccone, and
C E Grossi, and
L MacKenzie, and
P M Lydyard
May 1992,
Annals of the New York Academy of Sciences,
M D Smith, and
C Worman, and
F Yüksel, and
B Yüksel, and
L Moretta, and
E Ciccone, and
C E Grossi, and
L MacKenzie, and
P M Lydyard
September 1995,
The Journal of investigative dermatology,
