BIOMAT Database Logo BIOMAT Database Logo

Impact of concomitant aortic regurgitation on long-term outcome after surgical aortic valve replacement in patients with severe aortic stenosis. 2011

Suad Catovic, and Zoran B Popovic, and Nebojsa Tasic, and Dusko Nezic, and Predrag Milojevic, and Bosko Djukanovic, and Sinisa Gradinac, and Lazar Angelkov, and Petar Otasevic
General Hospital, Novi Pazar, Serbia.

BACKGROUND Prognostic value of concomitant aprtic regurgitation (AR) in patients operated for severe aortic stenosis (AS) is not clarified. The aim of this study was to prospectively examine the impact of presence and severity of concomitant AR in patients operated for severe AS on long-term functional capacity, left ventricular (LV) function and mortality. METHODS Study group consisted of 110 consecutive patients operated due to severe AS. The patients were divided into AS group (56 patients with AS without AR or with mild AR) and AS+AR group (54 patients with AS and moderate, severe or very severe AR). Follow-up included clinical examination, six minutes walk test (6MWT) and echocardiography 12 and 104 months after AVR. RESULTS Patients in AS group had lower LV volume indices throughout the study than patients in AS+AR group. Patients in AS group did not have postoperative decrease in LV volume indices, whereas patients in AS+AR group experienced decrease in LV volume indices at 12 and 104 months. Unlike LV volume indices, LV mass index was significantly lower in both groups after 12 and 104 months as compared to preoperative values. Mean LVEF remained unchanged in both groups throughout the study. NYHA class was improved in both groups at 12 months, but at 104 months remained improved only in patients with AS. On the other hand, distance covered during 6MWT was longer at 104 months as compared to 12 months only in AS+AR group (p = 0,013), but patients in AS group walked longer at 12 months than patients in AS+AR group (p = 0,002). There were 30 deaths during study period, of which 13 (10 due to cardiovascular causes) in AS group and 17 (12 due to cardiovascular causes) in AS+AR group. Kaplan-Meier analysis showed that the survival probability was similar between the groups. Multivariate analysis identified diabetes mellitus (beta 1.78, p = 0.038) and LVEF < 45% (beta 1.92, p = 0.049) as the only independent predictor of long-term mortality. CONCLUSIONS Our data indicate that the preoperative presence and severity of concomitant AR has no influence on long-term postoperative outcome, LV function and functional capacity in patients undergoing AVR for severe AS.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D004452 Echocardiography Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic. Echocardiography, Contrast,Echocardiography, Cross-Sectional,Echocardiography, M-Mode,Echocardiography, Transthoracic,Echocardiography, Two-Dimensional,Transthoracic Echocardiography,2-D Echocardiography,2D Echocardiography,Contrast Echocardiography,Cross-Sectional Echocardiography,Echocardiography, 2-D,Echocardiography, 2D,M-Mode Echocardiography,Two-Dimensional Echocardiography,2 D Echocardiography,Cross Sectional Echocardiography,Echocardiography, 2 D,Echocardiography, Cross Sectional,Echocardiography, M Mode,Echocardiography, Two Dimensional,M Mode Echocardiography,Two Dimensional Echocardiography
D005080 Exercise Test Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used. Arm Ergometry Test,Bicycle Ergometry Test,Cardiopulmonary Exercise Testing,Exercise Testing,Step Test,Stress Test,Treadmill Test,Cardiopulmonary Exercise Test,EuroFit Tests,Eurofit Test Battery,European Fitness Testing Battery,Fitness Testing,Physical Fitness Testing,Arm Ergometry Tests,Bicycle Ergometry Tests,Cardiopulmonary Exercise Tests,Ergometry Test, Arm,Ergometry Test, Bicycle,Ergometry Tests, Arm,Ergometry Tests, Bicycle,EuroFit Test,Eurofit Test Batteries,Exercise Test, Cardiopulmonary,Exercise Testing, Cardiopulmonary,Exercise Tests,Exercise Tests, Cardiopulmonary,Fitness Testing, Physical,Fitness Testings,Step Tests,Stress Tests,Test Battery, Eurofit,Test, Arm Ergometry,Test, Bicycle Ergometry,Test, Cardiopulmonary Exercise,Test, EuroFit,Test, Exercise,Test, Step,Test, Stress,Test, Treadmill,Testing, Cardiopulmonary Exercise,Testing, Exercise,Testing, Fitness,Testing, Physical Fitness,Tests, Arm Ergometry,Tests, Bicycle Ergometry,Tests, Cardiopulmonary Exercise,Tests, EuroFit,Tests, Exercise,Tests, Step,Tests, Stress,Tests, Treadmill,Treadmill Tests
D005260 Female Females
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001022 Aortic Valve Insufficiency Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root). Aortic Incompetence,Aortic Regurgitation,Aortic Valve Incompetence,Regurgitation, Aortic Valve,Incompetence, Aortic,Incompetence, Aortic Valve,Insufficiency, Aortic Valve,Regurgitation, Aortic
D001024 Aortic Valve Stenosis A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA. Aortic Stenosis,Aortic Valve Stenoses,Stenoses, Aortic,Stenoses, Aortic Valve,Stenosis, Aortic,Stenosis, Aortic Valve,Valve Stenoses, Aortic,Valve Stenosis, Aortic
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective

Related Publications

Suad Catovic, and Zoran B Popovic, and Nebojsa Tasic, and Dusko Nezic, and Predrag Milojevic, and Bosko Djukanovic, and Sinisa Gradinac, and Lazar Angelkov, and Petar Otasevic
Impact of concomitant tricuspid regurgitation on long-term outcomes in severe aortic stenosis.
March 2019, European heart journal. Cardiovascular Imaging,
Suad Catovic, and Zoran B Popovic, and Nebojsa Tasic, and Dusko Nezic, and Predrag Milojevic, and Bosko Djukanovic, and Sinisa Gradinac, and Lazar Angelkov, and Petar Otasevic
Impact of Valve Replacement on Long-Term Survival in Asymptomatic Patients With Severe Aortic Stenosis.
April 2019, The American journal of cardiology,
Suad Catovic, and Zoran B Popovic, and Nebojsa Tasic, and Dusko Nezic, and Predrag Milojevic, and Bosko Djukanovic, and Sinisa Gradinac, and Lazar Angelkov, and Petar Otasevic
Impact of Preoperative Left Ventricular Remodelling Patterns on Long-Term Outcome after Aortic Valve Replacement for Severe Aortic Stenosis.
January 2018, Cardiology,
Suad Catovic, and Zoran B Popovic, and Nebojsa Tasic, and Dusko Nezic, and Predrag Milojevic, and Bosko Djukanovic, and Sinisa Gradinac, and Lazar Angelkov, and Petar Otasevic
Long term effects of surgical and transcatheter aortic valve replacement on FFRCT in patients with severe aortic valve stenosis.
February 2022, The international journal of cardiovascular imaging,
Suad Catovic, and Zoran B Popovic, and Nebojsa Tasic, and Dusko Nezic, and Predrag Milojevic, and Bosko Djukanovic, and Sinisa Gradinac, and Lazar Angelkov, and Petar Otasevic
Prognostic impact and change of concomitant mitral regurgitation after surgical or transcatheter aortic valve replacement for aortic stenosis.
June 2016, Journal of cardiology,
Suad Catovic, and Zoran B Popovic, and Nebojsa Tasic, and Dusko Nezic, and Predrag Milojevic, and Bosko Djukanovic, and Sinisa Gradinac, and Lazar Angelkov, and Petar Otasevic
Indices predicting long-term survival after valve replacement in patients with aortic regurgitation and patients with aortic stenosis.
December 1974, Circulation,
Suad Catovic, and Zoran B Popovic, and Nebojsa Tasic, and Dusko Nezic, and Predrag Milojevic, and Bosko Djukanovic, and Sinisa Gradinac, and Lazar Angelkov, and Petar Otasevic
Importance of concomitant functional mitral regurgitation on survival in severe aortic stenosis patients undergoing aortic valve replacement.
May 2023, World journal of cardiology,
Suad Catovic, and Zoran B Popovic, and Nebojsa Tasic, and Dusko Nezic, and Predrag Milojevic, and Bosko Djukanovic, and Sinisa Gradinac, and Lazar Angelkov, and Petar Otasevic
Effect of concomitant aortic regurgitation on early hypoattenuated leaflet thickening after transcatheter aortic valve replacement in patients with symptomatic severe aortic stenosis.
December 2020, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Suad Catovic, and Zoran B Popovic, and Nebojsa Tasic, and Dusko Nezic, and Predrag Milojevic, and Bosko Djukanovic, and Sinisa Gradinac, and Lazar Angelkov, and Petar Otasevic
Impact of ejection fraction on long-term outcome after elective aortic valve replacement in octogenarians with aortic stenosis.
January 2012, Circulation journal : official journal of the Japanese Circulation Society,
Suad Catovic, and Zoran B Popovic, and Nebojsa Tasic, and Dusko Nezic, and Predrag Milojevic, and Bosko Djukanovic, and Sinisa Gradinac, and Lazar Angelkov, and Petar Otasevic
Impact of paravalvular regurgitation on the mid-term outcome after transcatheter and surgical aortic valve replacement.
December 2020, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Copied contents to your clipboard!