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An attempt was made to elucidate the pathogenesis of hepatoma. The material comprises 20 cases which were followed up more than 3 years after diagnosed liver cirrhosis and verified by autopsy. Hepatoma was found in 10 out of these 20 cases (50%). The follow-up period of these 10 cases with hepatoma was from 3 to 9.5 years (the mean value; 5.5 years). All 10 cases were not heavy drinkers, and showed liver cirrhosis of the mixed type by autopsy. HBsAG was positive in 6 out of 8 cases by RIA method (75%), and alpha-f was also detected in 5 of 7 cases by RIA method (70%). On the contrary, only 2 out of 10 cases without hepatoma were HBsAG positive (20%). The present results indicate that HBsAG positive liver cirrhosis of the mixed type is closely related to hepatoma in our country.
K Kobayashi, and
M Kumagai, and
S Kameda, and
T Sugimoto, and
K Suzuki, and
K Nishimura, and
Y Kato, and
G Sugioka, and
N Hattori
August 1983,
Klinicheskaia meditsina,
K Kobayashi, and
M Kumagai, and
S Kameda, and
T Sugimoto, and
K Suzuki, and
K Nishimura, and
Y Kato, and
G Sugioka, and
N Hattori
October 1991,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
K Kobayashi, and
M Kumagai, and
S Kameda, and
T Sugimoto, and
K Suzuki, and
K Nishimura, and
Y Kato, and
G Sugioka, and
N Hattori
May 1994,
The Italian journal of gastroenterology,
K Kobayashi, and
M Kumagai, and
S Kameda, and
T Sugimoto, and
K Suzuki, and
K Nishimura, and
Y Kato, and
G Sugioka, and
N Hattori
January 2011,
Transplantation proceedings,
K Kobayashi, and
M Kumagai, and
S Kameda, and
T Sugimoto, and
K Suzuki, and
K Nishimura, and
Y Kato, and
G Sugioka, and
N Hattori
August 1995,
Transplantation proceedings,
K Kobayashi, and
M Kumagai, and
S Kameda, and
T Sugimoto, and
K Suzuki, and
K Nishimura, and
Y Kato, and
G Sugioka, and
N Hattori
May 1993,
Archives of disease in childhood,
K Kobayashi, and
M Kumagai, and
S Kameda, and
T Sugimoto, and
K Suzuki, and
K Nishimura, and
Y Kato, and
G Sugioka, and
N Hattori
January 1971,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
K Kobayashi, and
M Kumagai, and
S Kameda, and
T Sugimoto, and
K Suzuki, and
K Nishimura, and
Y Kato, and
G Sugioka, and
N Hattori
January 1996,
Hepato-gastroenterology,
K Kobayashi, and
M Kumagai, and
S Kameda, and
T Sugimoto, and
K Suzuki, and
K Nishimura, and
Y Kato, and
G Sugioka, and
N Hattori
July 2009,
European journal of internal medicine,
K Kobayashi, and
M Kumagai, and
S Kameda, and
T Sugimoto, and
K Suzuki, and
K Nishimura, and
Y Kato, and
G Sugioka, and
N Hattori
February 1994,
Obesity surgery,
