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Discovery of new antimalarial chemotypes through chemical methodology and library development. 2011
Lauren E Brown, and
Ken Chih-Chien Cheng, and
Wan-Guo Wei, and
Pingwei Yuan, and
Peng Dai, and
Richard Trilles, and
Feng Ni, and
Jing Yuan, and
Ryan MacArthur, and
Rajarshi Guha, and
Ronald L Johnson, and
Xin-zhuan Su, and
Melissa M Dominguez, and
John K Snyder, and
Aaron B Beeler, and
Scott E Schaus, and
James Inglese, and
John A Porco
Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, MA 02215.
In an effort to expand the stereochemical and structural complexity of chemical libraries used in drug discovery, the Center for Chemical Methodology and Library Development at Boston University has established an infrastructure to translate methodologies accessing diverse chemotypes into arrayed libraries for biological evaluation. In a collaborative effort, the NIH Chemical Genomics Center determined IC(50)'s for Plasmodium falciparum viability for each of 2,070 members of the CMLD-BU compound collection using quantitative high-throughput screening across five parasite lines of distinct geographic origin. Three compound classes displaying either differential or comprehensive antimalarial activity across the lines were identified, and the nascent structure activity relationships (SAR) from this experiment used to initiate optimization of these chemotypes for further development.
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