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Predictors of CD4 eligibility for antiretroviral therapy initiation among HIV-infected pregnant women in Lusaka, Zambia. 2011
Katherine C Liu, and
Jessica Mulindwa, and
Mark J Giganti, and
Nande B Putta, and
Namwinga Chintu, and
Benjamin H Chi, and
Jeffrey S A Stringer, and
Elizabeth M Stringer
Centre for Infectious Disease Research in Zambia, Lusaka, Zambia. cherry.liu@cidrz.org
BACKGROUND In resource-limited settings, CD4 testing is a barrier to antiretroviral therapy initiation in pregnancy. METHODS We used logistic regression to identify predictors of CD4 cell count ≤ 350 cells/uL in 20,233 pregnant women. RESULTS The best-performing model included any 3 of: age ≥ 28 years old, hemoglobin ≤ 9.8 g/dL, gestational age ≤ 30 weeks, weight ≤ 64 kg, history of tuberculosis or previous death of an infant prior to one year old. Sensitivity was 45.7% (95% CI: 44.5-47.0), specificity 70.7% (95% CI: 69.6-71.8), and misclassification rate 41.4% (95% CI: 40.5-42.2). CONCLUSIONS CD4 triage remains a critical element of maternal HIV care and PMTCT.
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