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An intensive short-term triamcinolone regimen in cats preserves the prejunctional actions of edrophonium in degenerating motor nerves. These edrophonium actions include the induction of a stimulus-dependent afterdischarge and the initiation of fasciculations. The relationship between fasciculations and stimulus-dependent afterdischarge is discussed. The glucocorticoid preservation of these edrophonium effects is like that previously reported for the preservation of posttetanic facilitation in motor nerves equally compromised. The results therefore show that glucocorticoid and facilitatory drug actions synergize to increase facilitation in degenerating but still functional motor nerves. This drug synergy is comparable to that which occurs in normal motor nerves. This interaction may provide a basis for effectively combining glucocorticoid and facilitatory drugs in the treatment of myasthenia gravis.
E D Hall, and
W F Riker, and
T Baker
December 1978,
The Journal of physiology,
E D Hall, and
W F Riker, and
T Baker
December 1976,
The Journal of pharmacology and experimental therapeutics,
E D Hall, and
W F Riker, and
T Baker
July 1966,
The American journal of physiology,
E D Hall, and
W F Riker, and
T Baker
August 1962,
The Journal of physiology,
E D Hall, and
W F Riker, and
T Baker
March 1978,
Experimental neurology,
E D Hall, and
W F Riker, and
T Baker
December 1965,
The Journal of physiology,
E D Hall, and
W F Riker, and
T Baker
January 1992,
Anatomy and embryology,
E D Hall, and
W F Riker, and
T Baker
April 1963,
The Journal of physiology,
E D Hall, and
W F Riker, and
T Baker
February 1968,
The Journal of pharmacology and experimental therapeutics,
E D Hall, and
W F Riker, and
T Baker
January 1987,
Life sciences,
