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Piribedil, a compound that stimulates dopamine receptors in a relatively specific fashion, was administered to 11 hospitalized depressed patients. The dopamine agonist significantly decreased rapid eye movement (REM) sleep and percent REM sleep and increased REM latency. Piribedil decreased the probenecid-induced accumulation of the dopamine metabolite homovanillic acid (HVA) in CSF. A range of mild to moderate antidepressant effects was noted; one patient worsened and one developed recurrent manic episodes. The degree of improvement in depression was negatively correlated with pretreatment values of HVA in CSF (r = -.66, P less than .05). These data suggest that the heterogeneity of clinical response may be related to biological differences in depressed patients and that those with low initial dopaminergic function respond best to increased dopamine receptor stimulation.
R M Post, and
R H Gerner, and
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J C Gillin, and
D C Jimerson, and
F K Goodwin, and
W E Bunney
January 1986,
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R M Post, and
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F K Goodwin, and
W E Bunney
December 1974,
Clinical pharmacology and therapeutics,
R M Post, and
R H Gerner, and
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September 1983,
Archives of general psychiatry,
R M Post, and
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January 1980,
Communications in psychopharmacology,
R M Post, and
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J C Gillin, and
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W E Bunney
December 1986,
The American journal of psychiatry,
R M Post, and
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February 2002,
Fundamental & clinical pharmacology,
R M Post, and
R H Gerner, and
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J C Gillin, and
D C Jimerson, and
F K Goodwin, and
W E Bunney
October 1971,
Life sciences. Pt. 1: Physiology and pharmacology,
R M Post, and
R H Gerner, and
J S Carman, and
J C Gillin, and
D C Jimerson, and
F K Goodwin, and
W E Bunney
October 1995,
Vision research,
R M Post, and
R H Gerner, and
J S Carman, and
J C Gillin, and
D C Jimerson, and
F K Goodwin, and
W E Bunney
January 1997,
Journal of neural transmission (Vienna, Austria : 1996),
R M Post, and
R H Gerner, and
J S Carman, and
J C Gillin, and
D C Jimerson, and
F K Goodwin, and
W E Bunney
January 1983,
Progress in neuro-psychopharmacology & biological psychiatry,
