Myocardial contractility is preserved early but reduced late after ovariectomy in young female rats. 2011

Altemar S Paigel, and Rogerio F Ribeiro, and Aurelia A Fernandes, and Gabriel P Targueta, and Dalton V Vassallo, and Ivanita Stefanon
Federal University of Espirito Santo, Department of Physiological Sciences, Vitória, ES, Brazil.

BACKGROUND Ovarian sex hormones (OSHs) are implicated in cardiovascular function. It has been shown that OSHs play an important role in the long term regulation of cardiac sarcoplasmic reticulum (SR) function and contractility, although early effects of OSHs deprivation on myocardial contractility have not yet been determined. This study evaluated the early and late effects of OSHs deficiency on left ventricular contractility in rats after ovariectomy. METHODS Young female Wistar rats were divided into 3 groups (n=9-15): sham operated (Sham), ovariectomized (Ovx) and Ovx treated with estradiol (1 mg/kg, i.m., once a week) (Ovx+E2). After 7, 15, 30 and 60 days post Ovx, left ventricle papillary muscle was mounted for isometric tension recordings. The inotropic response to Ca2+ (0.62 to 3.75 mM) and isoproterenol (Iso 10-8 to 10-2 M) and contractility changes in response to rate changes (0.25 to 3 Hz) were assessed. Protein expression of SR Ca2+-ATPase (SERCA2a) and phospholamban (PLB) in the heart was also examined. RESULTS The positive inotropic response to Ca2+ and Iso at 7, 15, and 30 days after Ovx was preserved. However, at 60 days, the Ovx group had decreased myocardial contractility which was subsequently restored with E2 replacement. The reduction in SERCA2a and increase in PLB expression observed at 60 days after Ovx were restored with E2 replacement. CONCLUSIONS This study demonstrated that myocardial contractility and expression of key Ca2+ handling proteins were preserved in the early phase and reduced at long-term during OSHs deprivation.

UI MeSH Term Description Entries
D007537 Isometric Contraction Muscular contractions characterized by increase in tension without change in length. Contraction, Isometric,Contractions, Isometric,Isometric Contractions
D007545 Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant. Isoprenaline,Isopropylarterenol,4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol,Euspiran,Isadrin,Isadrine,Isopropyl Noradrenaline,Isopropylnoradrenaline,Isopropylnorepinephrine,Isoproterenol Hydrochloride,Isoproterenol Sulfate,Isuprel,Izadrin,Norisodrine,Novodrin,Hydrochloride, Isoproterenol,Noradrenaline, Isopropyl,Sulfate, Isoproterenol
D009200 Myocardial Contraction Contractile activity of the MYOCARDIUM. Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D010052 Ovariectomy The surgical removal of one or both ovaries. Castration, Female,Oophorectomy,Bilateral Ovariectomy,Bilateral Ovariectomies,Castrations, Female,Female Castration,Female Castrations,Oophorectomies,Ovariectomies,Ovariectomies, Bilateral,Ovariectomy, Bilateral
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D005260 Female Females
D000318 Adrenergic beta-Agonists Drugs that selectively bind to and activate beta-adrenergic receptors. Adrenergic beta-Receptor Agonists,beta-Adrenergic Agonists,beta-Adrenergic Receptor Agonists,Adrenergic beta-Agonist,Adrenergic beta-Receptor Agonist,Betamimetics,Receptor Agonists, beta-Adrenergic,Receptors Agonists, Adrenergic beta,beta-Adrenergic Agonist,beta-Adrenergic Receptor Agonist,Adrenergic beta Agonist,Adrenergic beta Agonists,Adrenergic beta Receptor Agonist,Adrenergic beta Receptor Agonists,Agonist, Adrenergic beta-Receptor,Agonist, beta-Adrenergic,Agonist, beta-Adrenergic Receptor,Agonists, Adrenergic beta-Receptor,Agonists, beta-Adrenergic,Agonists, beta-Adrenergic Receptor,Receptor Agonist, beta-Adrenergic,Receptor Agonists, beta Adrenergic,beta Adrenergic Agonist,beta Adrenergic Agonists,beta Adrenergic Receptor Agonist,beta Adrenergic Receptor Agonists,beta-Agonist, Adrenergic,beta-Agonists, Adrenergic,beta-Receptor Agonist, Adrenergic,beta-Receptor Agonists, Adrenergic
D000367 Age Factors Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time. Age Reporting,Age Factor,Factor, Age,Factors, Age
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Altemar S Paigel, and Rogerio F Ribeiro, and Aurelia A Fernandes, and Gabriel P Targueta, and Dalton V Vassallo, and Ivanita Stefanon
June 1984, Hormones and behavior,
Altemar S Paigel, and Rogerio F Ribeiro, and Aurelia A Fernandes, and Gabriel P Targueta, and Dalton V Vassallo, and Ivanita Stefanon
May 2007, Neuroscience,
Altemar S Paigel, and Rogerio F Ribeiro, and Aurelia A Fernandes, and Gabriel P Targueta, and Dalton V Vassallo, and Ivanita Stefanon
January 2006, Journal of cellular and molecular medicine,
Altemar S Paigel, and Rogerio F Ribeiro, and Aurelia A Fernandes, and Gabriel P Targueta, and Dalton V Vassallo, and Ivanita Stefanon
November 2021, Experimental gerontology,
Altemar S Paigel, and Rogerio F Ribeiro, and Aurelia A Fernandes, and Gabriel P Targueta, and Dalton V Vassallo, and Ivanita Stefanon
October 2009, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
Altemar S Paigel, and Rogerio F Ribeiro, and Aurelia A Fernandes, and Gabriel P Targueta, and Dalton V Vassallo, and Ivanita Stefanon
October 1994, Canadian journal of physiology and pharmacology,
Altemar S Paigel, and Rogerio F Ribeiro, and Aurelia A Fernandes, and Gabriel P Targueta, and Dalton V Vassallo, and Ivanita Stefanon
January 2002, Menopause (New York, N.Y.),
Altemar S Paigel, and Rogerio F Ribeiro, and Aurelia A Fernandes, and Gabriel P Targueta, and Dalton V Vassallo, and Ivanita Stefanon
January 1993, Veterinarni medicina,
Altemar S Paigel, and Rogerio F Ribeiro, and Aurelia A Fernandes, and Gabriel P Targueta, and Dalton V Vassallo, and Ivanita Stefanon
January 2018, PloS one,
Altemar S Paigel, and Rogerio F Ribeiro, and Aurelia A Fernandes, and Gabriel P Targueta, and Dalton V Vassallo, and Ivanita Stefanon
June 1973, The Journal of endocrinology,
Copied contents to your clipboard!