-transparent.png){kind=logo}
This article discusses the results of cytogenetic investigations of a cell line derived from a malignant tumor arising in a benign salivary gland pleomorphic adenoma. Initial karyotypic studies became possible with cells of the second in vitro passage and revealed the existence of hypertetraploidy. Furthermore, a marked polysomy 7 and a translocation involving 12q13-15, a breakpoint also frequently seen in benign pleomorphic adenomas, were noteworthy. During long term culture, the number of chromosomes per cell decreased as well as the number of copies of chromosome 7. Cell tumorigenicity was proved by heterotransplantation to nude mice. The resulting tumors were karyotyped again. No significant changes of the chromosome number or of the degree of polysomy 7 were found compared to the cells before heterotransplantation. In contrast, the cells from the nude mice tumors showed a remarkable number of different isochromosomes probably indicating an unknown factor supporting the generation of isochromosomes. The consistent presence of the t(12;?)(q13-15;?) makes the cell line well suited for molecular studies of this breakpoint region.
J Bullerdiek, and
K J Hutter, and
G Brandt, and
M Weinberg, and
G Belge, and
S Bartnitzke
March 1994,
Nihon Jibiinkoka Gakkai kaiho,
J Bullerdiek, and
K J Hutter, and
G Brandt, and
M Weinberg, and
G Belge, and
S Bartnitzke
January 1980,
Cancer,
J Bullerdiek, and
K J Hutter, and
G Brandt, and
M Weinberg, and
G Belge, and
S Bartnitzke
August 1987,
American journal of clinical pathology,
J Bullerdiek, and
K J Hutter, and
G Brandt, and
M Weinberg, and
G Belge, and
S Bartnitzke
August 1989,
The Journal of laryngology and otology,
J Bullerdiek, and
K J Hutter, and
G Brandt, and
M Weinberg, and
G Belge, and
S Bartnitzke
January 1985,
Jikken dobutsu. Experimental animals,
J Bullerdiek, and
K J Hutter, and
G Brandt, and
M Weinberg, and
G Belge, and
S Bartnitzke
September 2016,
Plastic and reconstructive surgery. Global open,
J Bullerdiek, and
K J Hutter, and
G Brandt, and
M Weinberg, and
G Belge, and
S Bartnitzke
March 1988,
Shika gakuho. Dental science reports,
J Bullerdiek, and
K J Hutter, and
G Brandt, and
M Weinberg, and
G Belge, and
S Bartnitzke
May 2023,
Annals of dermatology,
J Bullerdiek, and
K J Hutter, and
G Brandt, and
M Weinberg, and
G Belge, and
S Bartnitzke
October 2000,
Cytopathology : official journal of the British Society for Clinical Cytology,
J Bullerdiek, and
K J Hutter, and
G Brandt, and
M Weinberg, and
G Belge, and
S Bartnitzke
January 2002,
Auris, nasus, larynx,
