A model of hemorrhagic shock and acute lung injury in Landrace-Large White Swine. 2011

Theodoros T Xanthos, and Xanthippi A Balkamou, and Kostantinos I Stroumpoulis, and Ioannis N Pantazopoulos, and Georgios I Rokas, and Georgios D Agrogiannis, and Georgios T Troupis, and Theano D Demestiha, and Panagiotis N Skandalakis
Department of Anatomy, University of Athens Medical School, Athens, Greece. theodorosxanthos@yahoo.com

Traumatic injury is a leading cause of death worldwide for people between 5 and 44 y of age, and it accounts for 10% of all deaths. The incidence of acute lung injury, a life-threatening complication in severely injured trauma patients remains between 30% and 50%. This study describes an experimental protocol of volume-controlled hemorrhage in Landrace-Large White swine. The experimental approach simulated the clinical situation associated with hemorrhagic shock in the trauma patient while providing controlled conditions to maximize reproducibility. The duration of the protocol was 8 h and was divided into 5 distinct phases-stabilization, hemorrhage, maintenance, resuscitation, and observation-after which the swine were euthanized. Lung tissue samples were analyzed histologically. All swine survived the protocol. The hemodynamic responses accurately reflected those seen in humans, and the development of acute lung injury was consistent among all swine. This experimental protocol of hemorrhagic shock and fluid resuscitation in Landrace-Large White swine may be useful for future study of hemorrhagic shock and acute lung injury.

UI MeSH Term Description Entries
D011188 Potassium An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D006339 Heart Rate The number of times the HEART VENTRICLES contract per unit of time, usually per minute. Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006454 Hemoglobins The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements. Eryhem,Ferrous Hemoglobin,Hemoglobin,Hemoglobin, Ferrous
D006863 Hydrogen-Ion Concentration The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012771 Shock, Hemorrhagic Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA. Hemorrhagic Shock
D012964 Sodium A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23. Sodium Ion Level,Sodium-23,Ion Level, Sodium,Level, Sodium Ion,Sodium 23
D055371 Acute Lung Injury A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological). Lung Injury, Acute,Acute Lung Injuries,Lung Injuries, Acute
D019344 Lactic Acid A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed) Lactate,2-Hydroxypropanoic Acid,2-Hydroxypropionic Acid,Ammonium Lactate,D-Lactic Acid,L-Lactic Acid,Propanoic Acid, 2-Hydroxy-, (2R)-,Propanoic Acid, 2-Hydroxy-, (2S)-,Sarcolactic Acid,2 Hydroxypropanoic Acid,2 Hydroxypropionic Acid,D Lactic Acid,L Lactic Acid,Lactate, Ammonium

Related Publications

Theodoros T Xanthos, and Xanthippi A Balkamou, and Kostantinos I Stroumpoulis, and Ioannis N Pantazopoulos, and Georgios I Rokas, and Georgios D Agrogiannis, and Georgios T Troupis, and Theano D Demestiha, and Panagiotis N Skandalakis
July 2007, Laboratory animals,
Theodoros T Xanthos, and Xanthippi A Balkamou, and Kostantinos I Stroumpoulis, and Ioannis N Pantazopoulos, and Georgios I Rokas, and Georgios D Agrogiannis, and Georgios T Troupis, and Theano D Demestiha, and Panagiotis N Skandalakis
July 2011, Laboratory animals,
Theodoros T Xanthos, and Xanthippi A Balkamou, and Kostantinos I Stroumpoulis, and Ioannis N Pantazopoulos, and Georgios I Rokas, and Georgios D Agrogiannis, and Georgios T Troupis, and Theano D Demestiha, and Panagiotis N Skandalakis
March 2020, The Journal of surgical research,
Theodoros T Xanthos, and Xanthippi A Balkamou, and Kostantinos I Stroumpoulis, and Ioannis N Pantazopoulos, and Georgios I Rokas, and Georgios D Agrogiannis, and Georgios T Troupis, and Theano D Demestiha, and Panagiotis N Skandalakis
November 2012, Anesthesiology,
Theodoros T Xanthos, and Xanthippi A Balkamou, and Kostantinos I Stroumpoulis, and Ioannis N Pantazopoulos, and Georgios I Rokas, and Georgios D Agrogiannis, and Georgios T Troupis, and Theano D Demestiha, and Panagiotis N Skandalakis
March 2023, Scientific reports,
Theodoros T Xanthos, and Xanthippi A Balkamou, and Kostantinos I Stroumpoulis, and Ioannis N Pantazopoulos, and Georgios I Rokas, and Georgios D Agrogiannis, and Georgios T Troupis, and Theano D Demestiha, and Panagiotis N Skandalakis
July 2002, Resuscitation,
Theodoros T Xanthos, and Xanthippi A Balkamou, and Kostantinos I Stroumpoulis, and Ioannis N Pantazopoulos, and Georgios I Rokas, and Georgios D Agrogiannis, and Georgios T Troupis, and Theano D Demestiha, and Panagiotis N Skandalakis
August 2020, Annals of vascular surgery,
Theodoros T Xanthos, and Xanthippi A Balkamou, and Kostantinos I Stroumpoulis, and Ioannis N Pantazopoulos, and Georgios I Rokas, and Georgios D Agrogiannis, and Georgios T Troupis, and Theano D Demestiha, and Panagiotis N Skandalakis
June 1991, The Journal of trauma,
Theodoros T Xanthos, and Xanthippi A Balkamou, and Kostantinos I Stroumpoulis, and Ioannis N Pantazopoulos, and Georgios I Rokas, and Georgios D Agrogiannis, and Georgios T Troupis, and Theano D Demestiha, and Panagiotis N Skandalakis
January 1987, Circulatory shock,
Theodoros T Xanthos, and Xanthippi A Balkamou, and Kostantinos I Stroumpoulis, and Ioannis N Pantazopoulos, and Georgios I Rokas, and Georgios D Agrogiannis, and Georgios T Troupis, and Theano D Demestiha, and Panagiotis N Skandalakis
July 2014, The journal of trauma and acute care surgery,
Copied contents to your clipboard!