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Brain ischemia was produced by bilateral ligation of the common carotid arteries of spontaneously hypertensive rats. The concentrations of fructose 2,6-bisphosphate and other glycolytic intermediates as well as of pyridine and adenine nucleotides were measured in frozen brain samples. In contrast to the decrease reported in hepatocytes under anoxic conditions, the fructose 2,6-bisphosphate content was increased by 20-30% during the early stages of ischemia. Elevation in fructose 1,6-bisphosphate level and lactate formation followed the rise in fructose 2,6-bisphosphate content, a finding suggesting that this compound plays a key role in the compensatory acceleration of glycolysis under ischemic conditions in vivo.
M Yamamoto, and
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M Tomonaga
July 1991,
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M Yamamoto, and
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M Tomonaga
April 1992,
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M Yamamoto, and
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April 1990,
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M Yamamoto, and
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M Tomonaga
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M Yamamoto, and
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M Tomonaga
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M Yamamoto, and
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M Tomonaga
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M Yamamoto, and
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M Tomonaga
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M Yamamoto, and
N Hamasaki, and
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M Tomonaga
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M Yamamoto, and
N Hamasaki, and
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M Tomonaga
January 1987,
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M Yamamoto, and
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