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Colonies of nonhuman primates at the Bowman Gray School of Medicine (BGSM) were tested for antibodies to two retroviruses associated with immunodeficiency by indirect immunofluorescence (IFA) and western blot. A total of 471 cynomolgus macaques (Macaca fascicularis), 144 rhesus monkeys (M. mulatta) and 67 stumptail monkey M. arctoides) were tested for SRV-1, and 152 African green monkeys (Cercopithecus aethiops) were tested for SIV. Of the macaques tested, 170 (36%) cynomolgus, 5 (3%) rhesus and 8 (12%) stumptails were positive for SRV-1 antibodies by IFA. Of the African green monkeys, 54 (36%) were IFA positive for SIV antibodies. A total of 143 African green monkeys tested by IFA also were tested by western blot. In the African green monkeys, the IFA had a positive predictive value of 98% and a negative predictive value of 96%. Of 176 IFA positive macaque sera tested by western blot, 49 (28%) were positive, 55 (31%) were considered equivocal (only one band, usually to p27 core protein), and 72 (41%) were negative.
L Krugner-Higby, and
L Kucera, and
N Lerche, and
J Sever, and
W Fucillo, and
J Allan, and
R Benveniste
January 1993,
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L Krugner-Higby, and
L Kucera, and
N Lerche, and
J Sever, and
W Fucillo, and
J Allan, and
R Benveniste
June 1998,
Lancet (London, England),
L Krugner-Higby, and
L Kucera, and
N Lerche, and
J Sever, and
W Fucillo, and
J Allan, and
R Benveniste
November 1988,
Journal of virology,
L Krugner-Higby, and
L Kucera, and
N Lerche, and
J Sever, and
W Fucillo, and
J Allan, and
R Benveniste
January 1994,
Current topics in microbiology and immunology,
L Krugner-Higby, and
L Kucera, and
N Lerche, and
J Sever, and
W Fucillo, and
J Allan, and
R Benveniste
January 1989,
Journal of medical primatology,
L Krugner-Higby, and
L Kucera, and
N Lerche, and
J Sever, and
W Fucillo, and
J Allan, and
R Benveniste
June 2012,
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,
L Krugner-Higby, and
L Kucera, and
N Lerche, and
J Sever, and
W Fucillo, and
J Allan, and
R Benveniste
April 2008,
Journal of virology,
L Krugner-Higby, and
L Kucera, and
N Lerche, and
J Sever, and
W Fucillo, and
J Allan, and
R Benveniste
January 1987,
Microbiology and immunology,
L Krugner-Higby, and
L Kucera, and
N Lerche, and
J Sever, and
W Fucillo, and
J Allan, and
R Benveniste
March 1990,
AIDS research and human retroviruses,
L Krugner-Higby, and
L Kucera, and
N Lerche, and
J Sever, and
W Fucillo, and
J Allan, and
R Benveniste
October 1987,
Laboratory animal science,
