Biomaterial Database

The effect of sodium selenite supplementation on monensin-induced growth inhibition and residue accumulation in broiler chicks. 1990

P A VanderKop, and J D MacNeil

Toxicology Research Group, University of Saskatchewan, Saskatoon, Canada.

Ninety-six commercial broiler chicks housed in battery brooders were exposed to experimental diets varying in monensin (50, 250 mg/kg) and sodium selenite (0, 10 mg/kg) levels from their 10th to 25th day of age. Feed and water were supplied ad libitum. There were 4 replications of each experimental treatment, each with 6 birds/replication. The data on bird weights showed a significant treatment effect for monensin, sodium selenite, and an interaction between the 2. High levels of monensin and sodium selenite decreased weight, the combination exacerbating this response. The residue data showed that chicks accumulated significantly higher concentrations of selenium in their tissues when on diets high in sodium selenite. Chicks also accumulated significantly higher concentrations of monensin in their tissues when on diets high in monensin. An interactive effect was observed in terms of the selenium residue data, high levels of dietary monensin decreased the selenium residue concentration in the liver, kidney and cardiac muscle tissues when on high sodium selenite diets. No interactive effect was observed in terms of the monensin residue data. Pathological lesions, which were expected but not observed, may also indicate an interaction between these compounds.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008985	Monensin	An antiprotozoal agent produced by Streptomyces cinnamonensis. It exerts its effect during the development of first-generation trophozoites into first-generation schizonts within the intestinal epithelial cells. It does not interfere with hosts' development of acquired immunity to the majority of coccidial species. Monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies.	Coban,Monensin Monosodium Salt,Monensin Sodium,Monensin-A-Sodium Complex,Rumensin,Monensin A Sodium Complex
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D004032	Diet	Regular course of eating and drinking adopted by a person or animal.	Diets
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012643	Selenium	An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.	Selenium-80,Selenium 80
D018038	Sodium Selenite	The disodium salt of selenious acid. It is used therapeutically to supply the trace element selenium and is prepared by the reaction of SELENIUM DIOXIDE with SODIUM HYDROXIDE.	Disodium Selenite,Monosodium Selenite,Selenous Acid Disodium Salt,Selenous Acid, Disodium Salt,Sodium Biselenite,Sodium Selenite Pentahydrate,Biselenite, Sodium,Pentahydrate, Sodium Selenite,Selenite Pentahydrate, Sodium,Selenite, Disodium,Selenite, Monosodium,Selenite, Sodium