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T cell receptor beta-chain gene rearrangement without gamma-chain gene rearrangement in cutaneous T cell lymphoma: an unusual finding. 1990
V C Ho, and
E R Hansen, and
J T Elder, and
O Baadsgaard, and
G L Vejlsgaard, and
C A Hanson, and
K D Cooper
Department of Dermatology, University of Michigan, Ann Arbor 48109.
T cells from the blood and skin of a patient with cutaneous T cell lymphoma demonstrated rearrangement of the T cell receptor beta-chain gene in the absence of rearrangement of the gamma-chain gene. To our knowledge, this has not been previously reported. This finding was unexpected in light of prevailing concepts of T cell ontogeny. Potential explanations for it are discussed.
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