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Differential expression between PAX-6 and EN proteins in medulloblastoma. 1996
S Vincent, and
N Turque, and
S Plaza, and
P Dhellemmes, and
J Hladky, and
R Assaker, and
M Ruchoux, and
S Saule
CHRU LILLE,DEPT NEUROSURG,F-59037 LILLE,FRANCE. CHRU LILLE,DEPT NEUROPATHOL,F-59037 LILLE,FRANCE. INST PASTEUR,CNRS,EP56,LAB DIFFERENCIAT CELLULAIRE & MOL,F-59019 LILLE,FRANCE.
A collection of 28 medulloblastomas was analyzed for expression of the developmental control genes PAX-6 and EN by immunohistochemical staining. Sixteen medulloblastomas expressed both EN and PAX-6 but, when differentiation could be assessed in the positive areas, PAX-6 is expressed in the less differentiated cells. Since Drosophila en encodes a negative regulator, we overexpressed the chicken en-1 in retinal pigmented epithelium cells. This resulted in Pax-6 down regulation. These results suggest a regulatory loop between PAX-6 and EN, two molecular markers of medulloblastoma.
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