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Hemophagocytic syndrome secondary to cytomegalovirus infection in an infant. 2011

Anshu Gupta, and Rajiv Sen, and Charu Batra, and Dipankar Banerjee, and Anjali Gupta, and Medha Jain
Department of Pathology and Neurology, Institute of Human Behaviour and Allied Sciences (IHBAS), Delhi, India.

Virus associated hemophagocytic syndrome is a non-neoplastic, generalized histiocytic proliferation with prominent hemophagocytosis associated with a systemic viral infection. We report a case of cytomegalovirus (CMV) associated hemophagocytic syndrome in a 2 month old male child presenting with rashes, fever, hepatosplenomegaly, cervical lymphadenopathy and pancytopenia. Fine needle aspiration cytology and biopsy from cervical lymph nodes revealed prominent hemophagocytosis. Serology for CMV IgM was positive in both the mother and the child, suggesting recent infection. Possibly there was intrauterine transmission of the infection.

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