-transparent.png){kind=logo}
Loss of heterozygosity on chromosome 16q, expression of her2/neu and p53 mutations in endometrial cancer. 1995
G Massenkeil, and
R Caduff, and
H Oberhuber, and
I Schwartewaldhoff, and
P Diener, and
F Bannwart, and
H Walt, and
R Schafer
UNIV ZURICH HOSP,INST CLIN PATHOL,DEPT PATHOL,DIV CANC RES,CH-8091 ZURICH,SWITZERLAND. KANTONSSPITAL,INST PATHOL,CH-9000 ST GALLEN,SWITZERLAND. CITY HOSP TRIEMLI,INST PATHOL,CH-8047 ZURICH,SWITZERLAND. UNIV ZURICH HOSP,DEPT OBSTET & GYNECOL,RES DIV GYNECOL,CH-8091 ZURICH,SWITZERLAND.
We analyzed endometrial adenocarcinomas for mutations of the p53 anti-oncogene, expression of the HER2/neu oncogene and for loss of heterozygosity on chromosome 16q. p53 mutations were found in 3 of 25 tumors. Elevated expression of HER2/neu found in 7 of 24 tumors involves a mechanism other than gene amplification. LOH on chromosome 16q22-24 was observed in 4 of 13 informative tumors. Four of 25 endometrial tumors exhibited two or more alterations. Tumors with the highest HER2/neu protein level exhibited a negative progesterone receptor status. Accumulation of these changes may determine the biological behaviour of a subset of endometrial tumors.
| UI | MeSH Term | Description | Entries |
|---|
Related Publications
G Massenkeil, and
R Caduff, and
H Oberhuber, and
I Schwartewaldhoff, and
P Diener, and
F Bannwart, and
H Walt, and
R Schafer
July 1997,
Genes, chromosomes & cancer,
G Massenkeil, and
R Caduff, and
H Oberhuber, and
I Schwartewaldhoff, and
P Diener, and
F Bannwart, and
H Walt, and
R Schafer
July 1998,
Medical oncology (Northwood, London, England),
G Massenkeil, and
R Caduff, and
H Oberhuber, and
I Schwartewaldhoff, and
P Diener, and
F Bannwart, and
H Walt, and
R Schafer
February 2002,
The Journal of surgical research,
G Massenkeil, and
R Caduff, and
H Oberhuber, and
I Schwartewaldhoff, and
P Diener, and
F Bannwart, and
H Walt, and
R Schafer
January 1994,
Anticancer research,
G Massenkeil, and
R Caduff, and
H Oberhuber, and
I Schwartewaldhoff, and
P Diener, and
F Bannwart, and
H Walt, and
R Schafer
January 1994,
Cancer research,
G Massenkeil, and
R Caduff, and
H Oberhuber, and
I Schwartewaldhoff, and
P Diener, and
F Bannwart, and
H Walt, and
R Schafer
November 1996,
Gynecologic oncology,
G Massenkeil, and
R Caduff, and
H Oberhuber, and
I Schwartewaldhoff, and
P Diener, and
F Bannwart, and
H Walt, and
R Schafer
November 2005,
Cancer,
G Massenkeil, and
R Caduff, and
H Oberhuber, and
I Schwartewaldhoff, and
P Diener, and
F Bannwart, and
H Walt, and
R Schafer
September 2004,
Breast cancer research and treatment,
G Massenkeil, and
R Caduff, and
H Oberhuber, and
I Schwartewaldhoff, and
P Diener, and
F Bannwart, and
H Walt, and
R Schafer
September 2017,
Oncotarget,
G Massenkeil, and
R Caduff, and
H Oberhuber, and
I Schwartewaldhoff, and
P Diener, and
F Bannwart, and
H Walt, and
R Schafer
July 2009,
Zhonghua bing li xue za zhi = Chinese journal of pathology,
