-transparent.png){kind=logo}
Interactions of the potent phencyclidine receptor agonist MK-801 with the dopaminergic system were examined in various brain regions in the rat. MK-801 increased dopamine (DA) metabolism in the pyriform cortex, entorhinal cortex, prefrontal cortex, striatum, olfactory tubercle, amygdala, and septum without affecting DA metabolism in the cingulate cortex and nucleus accumbens. In pyriform cortex and amygdala, MK-801 was more potent than phencyclidine at increasing DA metabolism. Local injections of MK-801 into ventral tegmental area and into the amygdala/pyriform cortex interface indicated that MK-801 may act at the cell body as well as the nerve terminal level to increase DA metabolism and that ongoing dopaminergic neuronal activity is a prerequisite for full drug action.
T S Rao, and
H S Kim, and
J Lehmann, and
L L Martin, and
P L Wood
September 1989,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
T S Rao, and
H S Kim, and
J Lehmann, and
L L Martin, and
P L Wood
March 1987,
European journal of pharmacology,
T S Rao, and
H S Kim, and
J Lehmann, and
L L Martin, and
P L Wood
April 1993,
British journal of pharmacology,
T S Rao, and
H S Kim, and
J Lehmann, and
L L Martin, and
P L Wood
November 1991,
Molecular pharmacology,
T S Rao, and
H S Kim, and
J Lehmann, and
L L Martin, and
P L Wood
February 1996,
Brain research,
T S Rao, and
H S Kim, and
J Lehmann, and
L L Martin, and
P L Wood
October 1993,
Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology,
T S Rao, and
H S Kim, and
J Lehmann, and
L L Martin, and
P L Wood
November 2012,
Pharmacology, biochemistry, and behavior,
T S Rao, and
H S Kim, and
J Lehmann, and
L L Martin, and
P L Wood
March 1992,
Neuropeptides,
T S Rao, and
H S Kim, and
J Lehmann, and
L L Martin, and
P L Wood
January 1993,
European journal of pharmacology,
T S Rao, and
H S Kim, and
J Lehmann, and
L L Martin, and
P L Wood
April 1989,
Brain research bulletin,
