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The adrenal cortisol response to corticotropin appears to involve both calcium and cyclic adenosine 3',5'-monophosphate (cAMP) as intracellular mediators. In 10 healthy male volunteers, the short-term administration of theophylline, which affects both intracellular calcium and cAMP, lowered basal cortisol levels but augmented the in vivo cortisol response to short-term corticotropin stimulation. Short-term administration of nifedipine, a calcium channel antagonist, had no effect on basal or peak cortisol levels but reduced the incremental cortisol response to corticotropin. The effects of both theophylline and nifedipine, although statistically significant, were modest and of questionable clinical significance but should be considered in the interpretation of the clinical corticotropin stimulation test. They may also provide some insight into the post-receptor actions of corticotropin.
M T McDermott, and
T L Walden, and
M Bornemann, and
R J Sjoberg, and
F D Hofeldt, and
G S Kidd
May 1978,
Endocrinology,
M T McDermott, and
T L Walden, and
M Bornemann, and
R J Sjoberg, and
F D Hofeldt, and
G S Kidd
January 1981,
The Journal of allergy and clinical immunology,
M T McDermott, and
T L Walden, and
M Bornemann, and
R J Sjoberg, and
F D Hofeldt, and
G S Kidd
October 1972,
Zeitschrift fur Gastroenterologie,
M T McDermott, and
T L Walden, and
M Bornemann, and
R J Sjoberg, and
F D Hofeldt, and
G S Kidd
January 1986,
Bollettino della Societa italiana di biologia sperimentale,
M T McDermott, and
T L Walden, and
M Bornemann, and
R J Sjoberg, and
F D Hofeldt, and
G S Kidd
February 1976,
American journal of obstetrics and gynecology,
M T McDermott, and
T L Walden, and
M Bornemann, and
R J Sjoberg, and
F D Hofeldt, and
G S Kidd
April 1994,
Biology of reproduction,
M T McDermott, and
T L Walden, and
M Bornemann, and
R J Sjoberg, and
F D Hofeldt, and
G S Kidd
February 1987,
The Journal of clinical endocrinology and metabolism,
M T McDermott, and
T L Walden, and
M Bornemann, and
R J Sjoberg, and
F D Hofeldt, and
G S Kidd
March 1988,
British journal of clinical pharmacology,
M T McDermott, and
T L Walden, and
M Bornemann, and
R J Sjoberg, and
F D Hofeldt, and
G S Kidd
March 1986,
Brain research,
M T McDermott, and
T L Walden, and
M Bornemann, and
R J Sjoberg, and
F D Hofeldt, and
G S Kidd
January 1986,
Peptides,
