BIOMAT Database Logo BIOMAT Database Logo

1,3-Dimethyl-5-methyl-sulfonyl-1H-pyrazolo-[4,3-e][1,2,4]triazine. 2010

Mariusz Mojzych, and Zbigniew Karczmarzyk, and Waldemar Wysocki
Department of Chemistry, University of Podlasie, ul. 3 Maja 54, 08-110 Siedlce, Poland.

In the title compound, C(7)H(9)N(5)O(2)S, the pyrazolo-[4,3-e][1,2,4]triazine fused-ring system is essentially planar [maximum deviation = 0.0420 (3) Å]. In the crystal, mol-ecules related by twofold axes are linked into a mol-ecular net via inter-molecular C-H⋯O and C-H⋯N hydrogen bonds. π-π inter-actions are observed between the triazine and pyrazole rings of mol-ecules related by the the twofold axis and inversion symmetry with centroid-centroid distances of 3.778 (3) and 3.416 (3) Å, respectively.

UI MeSH Term Description Entries

Related Publications

Mariusz Mojzych, and Zbigniew Karczmarzyk, and Waldemar Wysocki
New pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors.
July 2015, Bioorganic & medicinal chemistry,
Mariusz Mojzych, and Zbigniew Karczmarzyk, and Waldemar Wysocki
The activity of pyrazolo[4,3-e][1,2,4]triazine and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulphonamide derivatives in monolayer and spheroid breast cancer cell cultures.
December 2024, Journal of enzyme inhibition and medicinal chemistry,
Mariusz Mojzych, and Zbigniew Karczmarzyk, and Waldemar Wysocki
Pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors with antitumor activity.
May 2014, Bioorganic & medicinal chemistry,
Mariusz Mojzych, and Zbigniew Karczmarzyk, and Waldemar Wysocki
Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives.
August 2020, Molecules (Basel, Switzerland),
Mariusz Mojzych, and Zbigniew Karczmarzyk, and Waldemar Wysocki
5-Chloro-methyl-1,3-dimethyl-1H-pyrazole.
October 2010, Acta crystallographica. Section E, Structure reports online,
Mariusz Mojzych, and Zbigniew Karczmarzyk, and Waldemar Wysocki
Synthesis of pyrazolo[4,3-e][1,2,4]triazine sulfonamides, novel Sildenafil analogs with tyrosinase inhibitory activity.
December 2014, Bioorganic & medicinal chemistry,
Mariusz Mojzych, and Zbigniew Karczmarzyk, and Waldemar Wysocki
Synthesis of chiral pyrazolo[4,3-e][1,2,4]triazine sulfonamides with tyrosinase and urease inhibitory activity.
December 2017, Journal of enzyme inhibition and medicinal chemistry,
Mariusz Mojzych, and Zbigniew Karczmarzyk, and Waldemar Wysocki
(E)-2-[(4-Chloro-1,3-dimethyl-1H-pyrazol-5-yl)methyl-eneamino]benzamide.
November 2009, Acta crystallographica. Section E, Structure reports online,
Mariusz Mojzych, and Zbigniew Karczmarzyk, and Waldemar Wysocki
Synthesis of the pyrazolo[4,3-e][1,2,4]triazine family of natural products: nostocine A, fluviol A, and pseudoiodinine.
May 2006, Journal of the American Chemical Society,
Mariusz Mojzych, and Zbigniew Karczmarzyk, and Waldemar Wysocki
QSAR study of pyrazolo[4,3-e][1,2,4]triazine sulfonamides against tumor-associated human carbonic anhydrase isoforms IX and XII.
December 2017, Computational biology and chemistry,
Copied contents to your clipboard!