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The effects of human recombinant interleukin 1 alpha (20 pg/1-2 micrograms/l) and 1 beta (200 pg/1-20 micrograms/l) on two systems of thyroid cells have been compared. The thyroglobulin and cAMP secretion and the DNA content of human thyroid cells cultured in monolayer and of continuously grown rat thyroid cells, Fischer rat thyroid cell line have been studied. The growth of the rat thyroid cell line was inhibited by interleukin 1 beta (20 ng/1-20 micrograms/l), but not by interleukin 1 alpha. None of the cytokines changed the cAMP production of the rat thyroid cells. In contrast, both cAMP production and thyroglobulin secretion were inhibited dose-dependently by the cytokines in human thyroid cells in secondary cultures. These results caution the interpretation and extrapolation of changes induced by interleukin 1 from one cell system to the other.
A K Rasmussen, and
L Kayser, and
K Bech, and
U Feldt-Rasmussen, and
H Perrild, and
K Bendtzen
March 2005,
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A K Rasmussen, and
L Kayser, and
K Bech, and
U Feldt-Rasmussen, and
H Perrild, and
K Bendtzen
May 1989,
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A K Rasmussen, and
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K Bendtzen
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A K Rasmussen, and
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K Bendtzen
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A K Rasmussen, and
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U Feldt-Rasmussen, and
H Perrild, and
K Bendtzen
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A K Rasmussen, and
L Kayser, and
K Bech, and
U Feldt-Rasmussen, and
H Perrild, and
K Bendtzen
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A K Rasmussen, and
L Kayser, and
K Bech, and
U Feldt-Rasmussen, and
H Perrild, and
K Bendtzen
January 1991,
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A K Rasmussen, and
L Kayser, and
K Bech, and
U Feldt-Rasmussen, and
H Perrild, and
K Bendtzen
January 1992,
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A K Rasmussen, and
L Kayser, and
K Bech, and
U Feldt-Rasmussen, and
H Perrild, and
K Bendtzen
October 1997,
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A K Rasmussen, and
L Kayser, and
K Bech, and
U Feldt-Rasmussen, and
H Perrild, and
K Bendtzen
August 1988,
The Journal of clinical investigation,
