BIOMAT Database Logo BIOMAT Database Logo

Clinical significance of aberrant DNA methylation in childhood acute lymphoblastic leukemia. 2011

Seisho Takeuchi, and Masahide Matsushita, and Martin Zimmermann, and Takayuki Ikezoe, and Naoki Komatsu, and Taku Seriu, and Martin Schrappe, and Claus R Bartram, and H Phillip Koeffler
Department of Medicine, Kochi Medical School, Oko-cho, Nankoku, Kochi 783-8505, Japan. takeuti@kochi-u.ac.jp

Methylation profile was analyzed in ninety-five patients with childhood acute lymphoblastic leukemia (ALL). Methylation of both MGMT and p16 genes were associated with higher age (p=0.01 and p=0.03, respectively). Methylation of both p15 and SHP1 genes occurred more frequently in T-ALL than in precursor B-ALL (p=0.02 and p=0.01, respectively). In contrast, methylation of the DAPK gene was more frequent in precursor B-ALL (p=0.01). Patients with methylation of multiple genes more likely had T cell phenotype, and are classified as medium/high risk (p=0.004 and p=0.03, respectively). These results suggest that methylation status is associated with clinicopathological features in childhood ALL.

UI MeSH Term Description Entries
D008297 Male Males
D011401 Promoter Regions, Genetic DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes. rRNA Promoter,Early Promoters, Genetic,Late Promoters, Genetic,Middle Promoters, Genetic,Promoter Regions,Promoter, Genetic,Promotor Regions,Promotor, Genetic,Pseudopromoter, Genetic,Early Promoter, Genetic,Genetic Late Promoter,Genetic Middle Promoters,Genetic Promoter,Genetic Promoter Region,Genetic Promoter Regions,Genetic Promoters,Genetic Promotor,Genetic Promotors,Genetic Pseudopromoter,Genetic Pseudopromoters,Late Promoter, Genetic,Middle Promoter, Genetic,Promoter Region,Promoter Region, Genetic,Promoter, Genetic Early,Promoter, rRNA,Promoters, Genetic,Promoters, Genetic Middle,Promoters, rRNA,Promotor Region,Promotors, Genetic,Pseudopromoters, Genetic,Region, Genetic Promoter,Region, Promoter,Region, Promotor,Regions, Genetic Promoter,Regions, Promoter,Regions, Promotor,rRNA Promoters
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D004273 DNA, Neoplasm DNA present in neoplastic tissue. Neoplasm DNA
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D015254 DNA Modification Methylases Enzymes that are part of the restriction-modification systems. They are responsible for producing a species-characteristic methylation pattern, on either adenine or cytosine residues, in a specific short base sequence in the host cell's own DNA. This methylated sequence will occur many times in the host-cell DNA and remain intact for the lifetime of the cell. Any DNA from another species which gains entry into a living cell and lacks the characteristic methylation pattern will be recognized by the restriction endonucleases of similar specificity and destroyed by cleavage. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. DNA Modification Methyltransferases,Modification Methylases,Methylases, DNA Modification,Methylases, Modification,Methyltransferases, DNA Modification,Modification Methylases, DNA,Modification Methyltransferases, DNA

Related Publications

Seisho Takeuchi, and Masahide Matsushita, and Martin Zimmermann, and Takayuki Ikezoe, and Naoki Komatsu, and Taku Seriu, and Martin Schrappe, and Claus R Bartram, and H Phillip Koeffler
[Clinical significance of CASP8AP2 gene methylation in childhood acute lymphoblastic leukemia].
February 2015, Zhongguo shi yan xue ye xue za zhi,
Seisho Takeuchi, and Masahide Matsushita, and Martin Zimmermann, and Takayuki Ikezoe, and Naoki Komatsu, and Taku Seriu, and Martin Schrappe, and Claus R Bartram, and H Phillip Koeffler
Aberrant EPHB4 gene methylation and childhood acute lymphoblastic leukemia.
October 2017, Oncology letters,
Seisho Takeuchi, and Masahide Matsushita, and Martin Zimmermann, and Takayuki Ikezoe, and Naoki Komatsu, and Taku Seriu, and Martin Schrappe, and Claus R Bartram, and H Phillip Koeffler
Aberrant DNA methylation of key genes and Acute Lymphoblastic Leukemia.
January 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
Seisho Takeuchi, and Masahide Matsushita, and Martin Zimmermann, and Takayuki Ikezoe, and Naoki Komatsu, and Taku Seriu, and Martin Schrappe, and Claus R Bartram, and H Phillip Koeffler
[Clinical Significance of SFRP1 Gene Methylation in Patients with Childhood Acute Lymphoblastic Leukemia].
April 2023, Zhongguo shi yan xue ye xue za zhi,
Seisho Takeuchi, and Masahide Matsushita, and Martin Zimmermann, and Takayuki Ikezoe, and Naoki Komatsu, and Taku Seriu, and Martin Schrappe, and Claus R Bartram, and H Phillip Koeffler
TET2 Promoter DNA Methylation and Expression in Childhood Acute Lymphoblastic Leukemia.
January 2016, Asian Pacific journal of cancer prevention : APJCP,
Seisho Takeuchi, and Masahide Matsushita, and Martin Zimmermann, and Takayuki Ikezoe, and Naoki Komatsu, and Taku Seriu, and Martin Schrappe, and Claus R Bartram, and H Phillip Koeffler
Clinical significance of CD34 expression in childhood acute lymphoblastic leukemia.
August 1993, Blood,
Seisho Takeuchi, and Masahide Matsushita, and Martin Zimmermann, and Takayuki Ikezoe, and Naoki Komatsu, and Taku Seriu, and Martin Schrappe, and Claus R Bartram, and H Phillip Koeffler
Clinical significance of CD10 expression in childhood acute lymphoblastic leukemia.
January 1993, Leukemia,
Seisho Takeuchi, and Masahide Matsushita, and Martin Zimmermann, and Takayuki Ikezoe, and Naoki Komatsu, and Taku Seriu, and Martin Schrappe, and Claus R Bartram, and H Phillip Koeffler
[Immunophenotyping and its clinical significance in childhood acute lymphoblastic leukemia].
March 2012, Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,
Seisho Takeuchi, and Masahide Matsushita, and Martin Zimmermann, and Takayuki Ikezoe, and Naoki Komatsu, and Taku Seriu, and Martin Schrappe, and Claus R Bartram, and H Phillip Koeffler
Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia.
December 2005, Annals of hematology,
Seisho Takeuchi, and Masahide Matsushita, and Martin Zimmermann, and Takayuki Ikezoe, and Naoki Komatsu, and Taku Seriu, and Martin Schrappe, and Claus R Bartram, and H Phillip Koeffler
FHIT promoter DNA methylation and expression analysis in childhood acute lymphoblastic leukemia.
October 2017, Oncology letters,
Copied contents to your clipboard!