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F-cell levels are altered with erythrocyte density in sickle cell disease. 2011
Sumanta Basu, and
Bisnu Prasad Dash, and
Dilip Kumar Patel, and
Sudipa Chakravarty, and
Amit Chakravarty, and
Debashis Banerjee, and
Abhijit Chakrabarti
Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, India.
Lighter cells from density fractionated erythrocytes of sickle cell disease (SCD) patients carry higher amount of externalized phosphatidylserine (PS) and cell surface glycophorins compared to the denser counterparts. Further analysis also revealed that the denser cells contained higher levels of fetal hemoglobin (HbF) compared to the lighter cells, supported by the presence of larger number of F-cells in these populations. In this report, we have found direct evidence on the higher survival of the HbF rich erythrocytes in SCD.
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