-transparent.png){kind=logo}
Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. 2011
Uttam Thapa, and
Pritam Thapa, and
Radha Karki, and
Minho Yun, and
Jae Hun Choi, and
Yurngdong Jahng, and
Eunyoung Lee, and
Kyung-Hwa Jeon, and
Younghwa Na, and
Eun-Mi Ha, and
Won-Jea Cho, and
Youngjoo Kwon, and
Eung-Seok Lee
College of Pharmacy, Yeungnam University, Kyongsan 712-749, Republic of Korea.
Designed and synthesized were a series of 5H-chromeno[4,3-b]pyridines with substitution at 2- and 4-positions with various 5- or 6-membered heteroaromatics as antitumor agents. They were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Structure-activity relationship study showed that 2-furyl or 2-thienyl at 2- or 4-position of central pyridine is crucial in displaying topo I or II inhibitory activity and cytotoxicity.
Related Publications
Uttam Thapa, and
Pritam Thapa, and
Radha Karki, and
Minho Yun, and
Jae Hun Choi, and
Yurngdong Jahng, and
Eunyoung Lee, and
Kyung-Hwa Jeon, and
Younghwa Na, and
Eun-Mi Ha, and
Won-Jea Cho, and
Youngjoo Kwon, and
Eung-Seok Lee
January 2015,
Bioorganic & medicinal chemistry,
Uttam Thapa, and
Pritam Thapa, and
Radha Karki, and
Minho Yun, and
Jae Hun Choi, and
Yurngdong Jahng, and
Eunyoung Lee, and
Kyung-Hwa Jeon, and
Younghwa Na, and
Eun-Mi Ha, and
Won-Jea Cho, and
Youngjoo Kwon, and
Eung-Seok Lee
July 2015,
Bioorganic & medicinal chemistry,
Uttam Thapa, and
Pritam Thapa, and
Radha Karki, and
Minho Yun, and
Jae Hun Choi, and
Yurngdong Jahng, and
Eunyoung Lee, and
Kyung-Hwa Jeon, and
Younghwa Na, and
Eun-Mi Ha, and
Won-Jea Cho, and
Youngjoo Kwon, and
Eung-Seok Lee
May 2013,
Bioorganic & medicinal chemistry letters,
Uttam Thapa, and
Pritam Thapa, and
Radha Karki, and
Minho Yun, and
Jae Hun Choi, and
Yurngdong Jahng, and
Eunyoung Lee, and
Kyung-Hwa Jeon, and
Younghwa Na, and
Eun-Mi Ha, and
Won-Jea Cho, and
Youngjoo Kwon, and
Eung-Seok Lee
February 2007,
Bioorganic & medicinal chemistry,
Uttam Thapa, and
Pritam Thapa, and
Radha Karki, and
Minho Yun, and
Jae Hun Choi, and
Yurngdong Jahng, and
Eunyoung Lee, and
Kyung-Hwa Jeon, and
Younghwa Na, and
Eun-Mi Ha, and
Won-Jea Cho, and
Youngjoo Kwon, and
Eung-Seok Lee
April 2004,
Bioorganic & medicinal chemistry letters,
Uttam Thapa, and
Pritam Thapa, and
Radha Karki, and
Minho Yun, and
Jae Hun Choi, and
Yurngdong Jahng, and
Eunyoung Lee, and
Kyung-Hwa Jeon, and
Younghwa Na, and
Eun-Mi Ha, and
Won-Jea Cho, and
Youngjoo Kwon, and
Eung-Seok Lee
April 2016,
Bioorganic & medicinal chemistry,
Uttam Thapa, and
Pritam Thapa, and
Radha Karki, and
Minho Yun, and
Jae Hun Choi, and
Yurngdong Jahng, and
Eunyoung Lee, and
Kyung-Hwa Jeon, and
Younghwa Na, and
Eun-Mi Ha, and
Won-Jea Cho, and
Youngjoo Kwon, and
Eung-Seok Lee
April 2005,
Bioorganic & medicinal chemistry letters,
Uttam Thapa, and
Pritam Thapa, and
Radha Karki, and
Minho Yun, and
Jae Hun Choi, and
Yurngdong Jahng, and
Eunyoung Lee, and
Kyung-Hwa Jeon, and
Younghwa Na, and
Eun-Mi Ha, and
Won-Jea Cho, and
Youngjoo Kwon, and
Eung-Seok Lee
January 2007,
Bioorganic & medicinal chemistry,
Uttam Thapa, and
Pritam Thapa, and
Radha Karki, and
Minho Yun, and
Jae Hun Choi, and
Yurngdong Jahng, and
Eunyoung Lee, and
Kyung-Hwa Jeon, and
Younghwa Na, and
Eun-Mi Ha, and
Won-Jea Cho, and
Youngjoo Kwon, and
Eung-Seok Lee
February 2006,
Bioorganic & medicinal chemistry,
Uttam Thapa, and
Pritam Thapa, and
Radha Karki, and
Minho Yun, and
Jae Hun Choi, and
Yurngdong Jahng, and
Eunyoung Lee, and
Kyung-Hwa Jeon, and
Younghwa Na, and
Eun-Mi Ha, and
Won-Jea Cho, and
Youngjoo Kwon, and
Eung-Seok Lee
March 1995,
Journal of medicinal chemistry,
