-transparent.png){kind=logo}
1. Adrenergic mechanisms play an important role in regulation of ACTH release. We used the alpha 2-adrenergic agonist, clonidine, as a central nervous system inhibitor of ACTH release to see if it would alter naloxone-induced ACTH secretion in normal human volunteers. 2. There was a significant blunting of the mean peak level of ACTH and the mean peak change of ACTH from basal as well as the area under the ACTH-time curve when clonidine was given prior to naloxone. 3. We conclude that clonidine, by blocking central noradrenergic pathways, which stimulate corticotropin-releasing hormone secretion, inhibits naloxone-induced ACTH secretion. This suggests that naloxone causes ACTH release through these same central noradrenergic pathways.
R V Jackson, and
J E Grice, and
A J Jackson, and
G I Hockings
September 1984,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
R V Jackson, and
J E Grice, and
A J Jackson, and
G I Hockings
January 1980,
Substance and alcohol actions/misuse,
R V Jackson, and
J E Grice, and
A J Jackson, and
G I Hockings
March 1980,
British journal of clinical pharmacology,
R V Jackson, and
J E Grice, and
A J Jackson, and
G I Hockings
April 1985,
Clinical endocrinology,
R V Jackson, and
J E Grice, and
A J Jackson, and
G I Hockings
May 1979,
The New England journal of medicine,
R V Jackson, and
J E Grice, and
A J Jackson, and
G I Hockings
July 1993,
Annals of the New York Academy of Sciences,
R V Jackson, and
J E Grice, and
A J Jackson, and
G I Hockings
September 1985,
Life sciences,
R V Jackson, and
J E Grice, and
A J Jackson, and
G I Hockings
March 1985,
Fertility and sterility,
R V Jackson, and
J E Grice, and
A J Jackson, and
G I Hockings
November 1987,
Anaesthesia and intensive care,
R V Jackson, and
J E Grice, and
A J Jackson, and
G I Hockings
May 1988,
Annals of emergency medicine,
