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Effects of SQ-14225 (0.1, 0.3, and 3.0 mg/kg, i.v.) on the pressor responses to angiotensin I (A-I) and on the arterial blood pressure were investigated in anesthetized mongrel dogs. All the three doses significantly inhibited A-I induced pressor response (70-80%), however reduction in the blood pressure was noted only with the highest dose used. Neither bilateral nephrectomy, autonomic ganglionic blockade nor pretreatment with saralasin, an angiotensin II antagonist, altered the hypotensive activity of SQ-14225 (3 mg/kg, i.v.). The results of this study indicate that significant inhibition of angiotensin converting enzyme does not result in a decrease in the blood pressure in dogs, and that the hypotension produced by SQ-14225 may involve a mechanism yet to be identified.
B S Jandhyala, and
G F Washington, and
M F Lokhandwala
April 1982,
Nihon Jinzo Gakkai shi,
B S Jandhyala, and
G F Washington, and
M F Lokhandwala
August 1979,
Canadian Medical Association journal,
B S Jandhyala, and
G F Washington, and
M F Lokhandwala
October 1980,
European journal of pharmacology,
B S Jandhyala, and
G F Washington, and
M F Lokhandwala
June 1980,
Acta endocrinologica,
B S Jandhyala, and
G F Washington, and
M F Lokhandwala
June 1979,
Endocrinologia japonica,
B S Jandhyala, and
G F Washington, and
M F Lokhandwala
January 1981,
Nephron,
B S Jandhyala, and
G F Washington, and
M F Lokhandwala
September 1981,
Revista clinica espanola,
B S Jandhyala, and
G F Washington, and
M F Lokhandwala
January 1981,
Clinical and experimental hypertension,
B S Jandhyala, and
G F Washington, and
M F Lokhandwala
June 1978,
Journal of neurochemistry,
B S Jandhyala, and
G F Washington, and
M F Lokhandwala
September 1979,
Research communications in chemical pathology and pharmacology,
